Profiling the clinical characteristics and surgical efficacy of laryngomalacia in children

作者全名："Xiao, Ling; Yang, Yang; Ding, Ling; Zhang, Zhihai; Li, Xuelei; Yao, Hongbing; Tang, Xinye"

作者地址："[Xiao, Ling; Yang, Yang; Ding, Ling; Zhang, Zhihai; Li, Xuelei; Yao, Hongbing; Tang, Xinye] Chongqing Med Univ, Dept Otolaryngol Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Xiao, Ling; Yang, Yang; Ding, Ling; Zhang, Zhihai; Li, Xuelei; Yao, Hongbing; Tang, Xinye] China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China; [Xiao, Ling; Yang, Yang; Ding, Ling; Zhang, Zhihai; Li, Xuelei; Yao, Hongbing; Tang, Xinye] Chongqing Key Lab Pediat, Chongqing, Peoples R China"

通信作者："Tang, XY (通讯作者)，Chongqing Med Univ, Dept Otolaryngol Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Chongqing, Peoples R China.; Tang, XY (通讯作者)，China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China.; Tang, XY (通讯作者)，Chongqing Key Lab Pediat, Chongqing, Peoples R China."

来源：EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001095063900001

JCR分区：Q2

影响因子：1.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Laryngomalacia; Supraglottoplasty; Inspiratory stridor; Children

摘要："Objective To analyze the clinical characteristics of laryngomalacia in Chinese children and explore the surgical efficacy and factors influencing severe laryngomalacia. Methods Children (0-18 years) diagnosed with laryngomalacia in our hospital from January 2016 to January 2022 were enrolled in this study. Clinical data of patients, including general conditions, clinical symptoms, grading and classification, medical comorbidities, surgical efficacy, and the risk factors influencing severe laryngomalacia were retrospectively analyzed. Results A total of 1810 children were enrolled (male:female; 2.02:1), among which most were infants under 1 year (77.18%). Inspiratory laryngeal stridor (69.56%) was the most common symptom. Most patients had mild laryngomalacia (79.28%), with type IV laryngomalacia being the most common classification (52.27%). Congenital heart disease (37.85%) was the most common medical comorbidity. A total of 168 severe laryngomalacia cases were treated via supraglottoplasty with an effective rate of 83.93%. Notably, preterm birth (OR = 3.868, 95% CI 1.340 similar to 11.168), low birth weight (OR = 4.517, 95% CI 1.477 similar to 13.819) and medical comorbidities (OR = 7.219, 95% CI 2.534 similar to 20.564) were independent risk factors for poor prognosis (P < 0.05). Conclusion Laryngomalacia is common among infants under the age of one, and it is mostly characterized by inspiratory laryngeal stridor with various medical comorbidity. Supraglottoplasty is the first treatment choice for severe laryngomalacia cases with high success rates. However, premature delivery, low birth weight, and medical comorbidities significantly affect the efficacy of surgery."

基金机构："Youth Innovation inFuture Medicine, Chongging Medical University [W0128]"

基金资助正文："Youth Innovation inFuture Medicine, Chongging Medical University (W0128)."