"Early adulthood weight change, midlife ""Life's essential 8"" health status and risk of cardiometabolic diseases: a chinese nationwide cohort study"

作者全名："Cao, Qiuyu; Li, Mian; Qin, Guijun; Yan, Li; He, Jiang; Xu, Min; Xu, Yu; Wang, Tiange; Chen, Yuhong; Wang, Shuangyuan; Lin, Hong; Zhao, Zhiyun; Gao, Zhengnan; Zeng, Tianshu; Hu, Ruying; Yu, Xuefeng; Chen, Gang; Su, Qing; Mu, Yiming; Chen, Lulu; Tang, Xulei; Wan, Qin; Wang, Guixia; Shen, Feixia; Luo, Zuojie; Qin, Yingfen; Chen, Li; Huo, Yanan; Li, Qiang; Ye, Zhen; Zhang, Yinfei; Liu, Chao; Wang, Youmin; Wu, Shengli; Yang, Tao; Deng, Huacong; Zhao, Jiajun; Shi, Lixin; Ning, Guang; Wang, Weiqing; Lu, Jieli; Bi, Yufang"

作者地址："[Cao, Qiuyu; Li, Mian; Xu, Min; Xu, Yu; Wang, Tiange; Chen, Yuhong; Wang, Shuangyuan; Lin, Hong; Zhao, Zhiyun; Ning, Guang; Wang, Weiqing; Lu, Jieli; Bi, Yufang] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Endocrine & Metab Dis, Shanghai Inst Endocrine & Metab Dis,Sch Med, 197 Rui Jin 2nd Rd, Shanghai 200025, Peoples R China; [Cao, Qiuyu; Li, Mian; Xu, Min; Xu, Yu; Wang, Tiange; Chen, Yuhong; Wang, Shuangyuan; Lin, Hong; Zhao, Zhiyun; Ning, Guang; Wang, Weiqing; Lu, Jieli; Bi, Yufang] Shanghai Jiao Tong Univ, Shanghai Natl Clin Res Ctr Metab Dis, Key Lab Endocrine & Metab Dis, Ruijin Hosp,Natl Hlth Commiss PR China,Shanghai Ke, Shanghai, Peoples R China; [Qin, Guijun] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Yan, Li] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China; [He, Jiang] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA; [Gao, Zhengnan] Dalian Municipal Cent Hosp, Dalian, Peoples R China; [Zeng, Tianshu; Chen, Lulu] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan, Peoples R China; [Hu, Ruying; Ye, Zhen] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China; [Yu, Xuefeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China; [Chen, Gang] Fujian Med Univ, Fujian Prov Hosp, Fuzhou, Peoples R China; [Su, Qing] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai, Peoples R China; [Mu, Yiming] Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China; [Tang, Xulei] Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China; [Wan, Qin] Southwest Med Univ, Affiliated Hosp, Luzhou, Peoples R China; [Wang, Guixia] First Hosp Jilin Univ, Changchun, Peoples R China; [Shen, Feixia] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China; [Luo, Zuojie; Qin, Yingfen] Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China; [Chen, Li] Shandong Univ, Qilu Hosp, Jinan, Peoples R China; [Huo, Yanan] Nanchang Univ, Jiangxi Prov Peoples Hosp, Nanchang, Peoples R China; [Li, Qiang] Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China; [Zhang, Yinfei] Cent Hosp Shanghai Jiading Dist, Shanghai, Peoples R China; [Liu, Chao] Jiangsu Prov Hosp Integrat Chinese & Western Med, Nanjing, Peoples R China; [Wang, Youmin] Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China; [Wu, Shengli] Karamay Municipal Peoples Hosp, Karamay, Peoples R China; [Yang, Tao] Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China; [Deng, Huacong] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhao, Jiajun] Shandong Univ, Shandong Prov Hosp, Jinan, Peoples R China; [Shi, Lixin] Guiqian Int Gen Hosp, Guiyang, Peoples R China"

通信作者："Lu, JL; Bi, YF (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Endocrine & Metab Dis, Shanghai Inst Endocrine & Metab Dis,Sch Med, 197 Rui Jin 2nd Rd, Shanghai 200025, Peoples R China.; Lu, JL; Bi, YF (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Natl Clin Res Ctr Metab Dis, Key Lab Endocrine & Metab Dis, Ruijin Hosp,Natl Hlth Commiss PR China,Shanghai Ke, Shanghai, Peoples R China."

来源：NUTRITION & METABOLISM

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001095275100001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：20

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Weight; Cardiovascular health; Cardiovascular disease; Diabetes

摘要："BackgroundThe association between weight change during early adulthood and cardiometabolic diseases remains uncertain in Chinese population. Whether the association varies with comprehensive cardiovascular health (CVH) in midlife assessed by ""Life's Essential 8"" has not been characterized. We aim to examine the associations of early adulthood weight change and midlife ""Life's Essential 8"" CVH status with cardiometabolic outcomes in a Chinese cohort.MethodsThe study participants were from the China Cardiometabolic Disease and Cancer Cohort (4 C) Study. This analysis included 72,610 middle-aged and older participants followed for a median of 3.6 years. At baseline, the participants recalled body weight at age 20 and 40 years, and we calculated change in weight and BMI between 20 and 40 years of age. Health behaviors information in ""Life's Essential 8"" was collected by questionnaire, and health factors were measured in the study center. During follow-up, we ascertained incident cardiovascular events based on medical records, and diagnosed incident diabetes according to the American Diabetes Association 2010 criteria.Results72,610 study participants were included with a mean age of 56.0 +/- 8.8 years and 29% of them were males. Weight gain of more than 10 kg between 20 and 40 years of age was associated with 22% increased risk of incident cardiovascular events (HR: 1.22; 95%CI: 1.04-1.43) and 38% increased risk of diabetes (HR: 1.38; 95%CI: 1.25-1.53) compared to stable weight. Besides, the association of weight gain more than 10 kg in early adulthood with cardiometabolic risk was even stronger in those with low CVH score in midlife (HR: 2.44; 95%CI: 2.01-2.97 for incident cardiovascular events; HR: 2.20; 95%CI: 1.90-2.55 for incident diabetes) or with few ideal cardiovascular health metrics in midlife.ConclusionsOur study indicated that weight gain in early adulthood was associated with significantly increased risk of cardiometabolic diseases. And the association could be stronger in those with poor CVH profiles in midlife. These findings confirmed the significance of weight management during early adulthood and suggested that individuals who experienced substantial weight gain in early life should be encouraged to maintain good CVH status in Chinese population."

基金机构：The investigators are grateful to all participants for their cooperation in this study.

基金资助正文：The investigators are grateful to all participants for their cooperation in this study.