"Multicenter analysis of epidemiological and clinical features of pediatric acute lower respiratory tract infections associated with common human coronaviruses in China, 2014-2019"

作者全名："Han, Shuaibing; Xu, Baoping; Feng, Qianyu; Feng, Ziheng; Zhu, Yun; Ai, Junhong; Deng, Li; Li, Changchong; Cao, Ling; Sun, Yun; Fu, Zhou; Jin, Rong; Shang, Yunxiao; Chen, Zhiming; Xu, Lili; Xie, Zhengde; Shen, Kunling"

作者地址："[Han, Shuaibing; Feng, Qianyu; Feng, Ziheng; Zhu, Yun; Ai, Junhong; Xu, Lili; Xie, Zhengde; Shen, Kunling] Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing Key Lab Pediat Resp Infect Dis,Key Lab Maj, Beijing 100045, Peoples R China; [Han, Shuaibing; Feng, Qianyu; Feng, Ziheng; Zhu, Yun; Ai, Junhong; Xu, Lili; Xie, Zhengde] Chinese Acad Med Sci, Res Unit Crit Infect Children, 2019RU016, Beijing 100045, Peoples R China; [Xu, Baoping] Capital Med Univ, Beijing Childrens Hosp, Natl Clin Res Ctr Resp Dis, Natl Ctr Childrens Hlth,Dept Resp Dis 1, Beijing 100045, Peoples R China; [Deng, Li] Guangzhou Women & Childrens Med Ctr, Guangzhou 510623, Peoples R China; [Li, Changchong] Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou 325027, Peoples R China; [Li, Changchong] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China; [Cao, Ling] Capital Inst Pediat, Childrens Hosp, Beijing 100020, Peoples R China; [Sun, Yun] Yinchuan Maternal & Child Hlth Hosp, Yinchuan 750000, Peoples R China; [Fu, Zhou] Chongqing Med Univ, Childrens Hosp, Chongqing 400015, Peoples R China; [Jin, Rong] Guiyang Women & Children Healthcare Hosp, Guiyang 550003, Peoples R China; [Shang, Yunxiao] China Med Univ, Shengjing Hosp, Shenyang 110004, Peoples R China; [Chen, Zhiming] Zhejiang Univ, Childrens Hosp, Sch Med, Hangzhou 310052, Peoples R China"

通信作者："Xu, LL; Xie, ZD; Shen, KL (通讯作者)，Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing Key Lab Pediat Resp Infect Dis,Key Lab Maj, Beijing 100045, Peoples R China.; Xu, LL; Xie, ZD (通讯作者)，Chinese Acad Med Sci, Res Unit Crit Infect Children, 2019RU016, Beijing 100045, Peoples R China."

来源：VIROLOGY JOURNAL

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001095506300003

JCR分区：Q2

影响因子：4

年份：2023

卷号：20

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Common human coronavirus; Children; Epidemiology; Clinical manifestation; Multicentre research

摘要："The common human coronaviruses (HCoVs) HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 which are members of the coronavirus family are long co-existed with humans and widely distributed globally. Common HCoVs usually cause mild, self-limited upper respiratory tract infections (URTI), and also associated with lower respiratory tract infections (LRTI), especially in children. However, there are little multicentre studies have been conducted in children of several different areas in China, and the epidemic potential of common HCoVs remains unclear. Understanding of the common HCoVs is valuable for clinical and public health. Herein, we retrospectively analysed the medical records of children with acute lower respiratory tract infection admitted to 9 hospitals from different regions in China from 2014 to 2019. Of the 124 patients who tested positive for coronaviruses, OC43 was the predominant type, accounting for 36.3% (45/124) of the detections. Children aged <= 6 months and 12-23 months had the highest detection rate of common HCoVs, and the detection rate gradually declined after 2 years old. These four HCoVs could be detected all year round. Among the areas of our study, the overall positive rate was higher in southern China, especially in Guangzhou (29/124, 23.4%). Moreover, common HCoV-positive patients were codetected with 9 other common respiratory pathogens. 229E (11/13, 84.6%) was the most frequently associated with codetection, with EV/RhV was the most frequently codetected virus. Cough (113/124, 91.1%) and fever (73/124, 58.9%) were the most common symptoms of common HCoVs infection."

基金机构：Not applicable.

基金资助正文：Not applicable.