Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy

作者全名："Hao, Shuai; Huang, He; Ma, Rui-Yan; Zeng, Xue; Duan, Chen-Yang"

作者地址："[Hao, Shuai; Huang, He; Ma, Rui-Yan; Zeng, Xue; Duan, Chen-Yang] Chongqing Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Chongqing 400010, Peoples R China; [Hao, Shuai] Nanjing Univ, Jinling Hosp, Affiliated Hosp, Res Inst Gen Surg,Med Sch, Nanjing 210002, Peoples R China; [Ma, Rui-Yan] Army Med Univ, Xinqiao Hosp, Dept Cardiovasc Surg, Chongqing 400037, Peoples R China; [Zeng, Xue] Chongqing Med Univ, Inst Brain Sci & Dis, Chongqing 400010, Peoples R China"

通信作者："Duan, CY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Chongqing 400010, Peoples R China."

来源：MILITARY MEDICAL RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001095764000001

JCR分区：Q1

影响因子：16.7

年份：2023

卷号：10

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Dynamin-related protein 1 (Drp1); Hypoxic-ischemic injury; Mitochondrial quality imbalance; Cell dysfunction; Organ damage

摘要："Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings. Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia. Dynamin-related protein 1 (Drp1) regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications, which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic injury. However, there is active controversy and gaps in knowledge regarding the modification, protein interaction, and functions of Drp1, which both hinder and promote development of Drp1 as a novel therapeutic target. Here, we summarize recent findings on the oligomeric changes, modification types, and protein interactions of Drp1 in various hypoxic-ischemic diseases, as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and hypoxia. Additionally, potential clinical translation prospects for targeting Drp1 are discussed. This review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases."

基金机构："This work was supported by the National Natural Science Foundation of China (82272252, 82270378), the Senior Medical Talents Program of Chongqing for Young and Middle-aged, and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medi [82272252, 82270378]; National Natural Science Foundation of China; Senior Medical Talents Program of Chongqing for Young and Middle-aged, and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University"

基金资助正文："This work was supported by the National Natural Science Foundation of China (82272252, 82270378), the Senior Medical Talents Program of Chongqing for Young and Middle-aged, and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University."