"Compliance with the EAT-Lancet diet and risk of colorectal cancer: a prospective cohort study in 98,415 American adults"

作者全名："Ren, Xiaorui; Yu, Chuanchuan; Peng, Linglong; Gu, Haitao; Xiao, Yi; Tang, Yunhao; He, Hongmei; Xiang, Ling; Wang, Yaxu; Jiang, Yahui"

作者地址："[Ren, Xiaorui; Peng, Linglong; Gu, Haitao; Xiao, Yi; Tang, Yunhao; He, Hongmei; Wang, Yaxu; Jiang, Yahui] Chongqing Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, Chongqing, Peoples R China; [Yu, Chuanchuan] Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat, Guangzhou, Guangdong, Peoples R China; [Xiang, Ling] Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Nutr, Chongqing, Peoples R China"

通信作者："Wang, YX; Jiang, YH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, Chongqing, Peoples R China.; Xiang, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Nutr, Chongqing, Peoples R China."

来源：FRONTIERS IN NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001095849200001

JCR分区：Q2

影响因子：4

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：EAT-lancet diet; colorectal cancer; cox hazards regression analysis; prostate; lung; colorectal; ovarian cancer screening trial

摘要："Background The EAT-Lancet diet (ELD) is a recommended dietary pattern for achieving simultaneous improvements in both individual health and environmental sustainability. While research on the association between ELD and colorectal cancer (CRC) remains scarce, the potential impact of nutrition on CRC prevention and progression is a topic of growing interest. This study aims to investigate the relationship between adherence to the ELD and the risk of CRC, shedding light on the role of nutrition in CRC prevention.Methods A total of 98,415 participants were included. A Diet History Questionnaire (DHQ) was used to collect dietary information, and an ELD score was used to assess adherence to ELD. Higher scores indicated greater adherence. Cox hazard regression analyses were conducted to examine whether there were associations between the ELD score and CRC risk. The restricted cubic spline (RCS) model was used to further explore the dose-response association between the ELD score and CRC incidence. Subgroup analyses were conducted to identify potential modifiers that interacted with ELD on CRC incidence, and sensitivity analyses were performed to evaluate the robustness of the established association.Results During a mean follow-up of 8.82 years, a total of 1,054 CRC cases were documented. We found a statistically significant correlation between the ELD score and CRC risk (Q4 vs. Q1: HR 0.81, 95% CI 0.67-0.98; P for trend = 0.034) after adjusting for potential confounders. No statistically significant associations were discovered between ELD adherence and CRC by anatomical site. Subgroup analyses found no interactional factor, sensitivity analyses, and the RCS model showed a robustness and linearity association (P-linearity >0.05).Conclusion We concluded that adherence to ELD contributes to the prevention of CRC."

基金机构："The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. Our study was supported by the General Project of Chongqing Natural Science Foundation, Chongqing Science and Technology Commission,; General Project of Chongqing Natural Science Foundation [cstc2021jcyj-msxmX0153, cstc2021jcyj-msxmX0112, CSTB2022NSCQ-MSX1005]; Chongqing Science and Technology Commission, China [kryc-yq-2110]; Kuanren Talents Project of the Second Affiliated Hospital of Chongqing Medical University in China"

基金资助正文："All authors sincerely thank the PLCO study team and the National Cancer Institute for access to data collected by the PLCO trial.r The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. Our study was supported by the General Project of Chongqing Natural Science Foundation, Chongqing Science and Technology Commission, China [cstc2021jcyj-msxmX0153 (LP)], [cstc2021jcyj-msxmX0112 (YW)], [CSTB2022NSCQ-MSX1005 (HG)], and the Kuanren Talents Project of the Second Affiliated Hospital of Chongqing Medical University in China [kryc-yq-2110 (HG)]. The funders had no role in the study design or implementation, data collection, management, analysis, or interpretation; manuscript preparation, review, or approval; or the decision to submit the manuscript for publication."