Real-world effectiveness of an intranasal spray A8G6 antibody cocktail in the post-exposure prophylaxis of COVID-19

作者全名："Li, Xiaosong; Peng, Pai; Deng, Haijun; Yang, Qian; Chen, Shi; Li, Benhua; He, Miao; Jin, Aishun; Yang, Zhu; Tang, Ni; Huang, Ailong"

作者地址："[Li, Xiaosong; Yang, Qian; Chen, Shi; Li, Benhua] Chongqing Med Univ, Clin Mol Med Testing Ctr, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Li, Xiaosong] Chongqing Med Univ, Inst Brain Sci & Dis, Key Lab Major Brain Dis & Aging Res, Minist Educ, Chongqing 400016, Peoples R China; [Peng, Pai; Deng, Haijun; Tang, Ni; Huang, Ailong] Chongqing Med Univ, Dept Infect Dis, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing, Peoples R China; [Peng, Pai; Deng, Haijun; Tang, Ni; Huang, Ailong] Chongqing Med Univ, Inst Viral Hepatitis, Affiliated Hosp 2, Chongqing, Peoples R China; [He, Miao] Chongqing Med Univ, Lab Anim Ctr, Chongqing, Peoples R China; [Jin, Aishun] Chongqing Med Univ, Coll Basic Med, Dept Immunol, Chongqing 400010, Peoples R China; [Jin, Aishun] Chongqing Med Univ, Chongqing Key Lab Basic & Translat Res Tumor Immun, Chongqing 400010, Peoples R China; [Yang, Zhu] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Tang, N; Huang, AL (通讯作者)，Chongqing Med Univ, Dept Infect Dis, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing, Peoples R China.; Tang, N; Huang, AL (通讯作者)，Chongqing Med Univ, Inst Viral Hepatitis, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：SIGNAL TRANSDUCTION AND TARGETED THERAPY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001095865700001

JCR分区：Q1

影响因子：40.8

年份：2023

卷号：8

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Previously, we identified an antibody combination A8G6 that showed promising efficacy in COVID-19 animal models and favorable safety profile in preclinical models as well as in a first-in-human trial. To evaluate the real-word efficacy of A8G6 neutralizing antibody nasal spray in post-exposure prophylaxis of COVID-19, an open-label, non-randomized, two-arm, blank-controlled, investigator-initiated trial was conducted in Chongqing, China (the register number: ChiCTR2200066416). High-risk healthy participants (18-65 years) within 72 h after close contact to COVID-19 patients were recruited and received a three-dose (1.4 mg/dose) A8G6 treatment daily or no treatment (blank control) for 7 consecutive days. SARS-CoV-2 infection occurred in 151/340 (44.4%) subjects in the blank control group and 12/173 (6.9%) subjects in the A8G6 treatment group. The prevention efficacy of the A8G6 treatment within 72 h exposure was calculated to be 84.4% (95% CI: 74.4-90.4%). Moreover, compared to the blank-control group, the time from the SARS-CoV-2 negative to the positive COVID-19 conversion was significantly longer in the AG86 treatment group (mean time: 3.4 days vs 2.6 days, p = 0.019). In the secondary end-point analysis, the A8G6 nasal treatment had no effects on the viral load at baseline SARS-CoV-2 RT-PCR positivity and the time of the negative COVID-19 conversion. Finally, except for 5 participants (3.1%) with general adverse effects, we did not observe any severe adverse effects related to the A8G6 treatment. In this study, the intranasal spray AG86 antibody cocktail showed potent efficacy for prevention of SARS-CoV-2 infection in close contacts of COVID-19 patients."

基金机构："We thank Dr. Yang Tian and Chengyong Yang (Mindao Haoyue Co., Ltd. Chongqing, China) for the constructive suggestion about the trial design and manuscript. We thank all the participants who took part and contribute specimens in our study. We also thank the; Yuzhong District Center for Disease Control and Prevention (Chongqing) [CSTB2022TIAD-STX0013]; Chongqing Biomedical Ramp;D Major Special Project [2022GDRC012]; Chongqing Science and Health Joint Medical High-end Talent Project [KJZD-K202100402]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202200466]; Science and Technology Reseearch Program of Chongqing Municipal Education Commission [W0073]; CQMU Program for Youth Innovation in Future Medicine"

基金资助正文："We thank Dr. Yang Tian and Chengyong Yang (Mindao Haoyue Co., Ltd. Chongqing, China) for the constructive suggestion about the trial design and manuscript. We thank all the participants who took part and contribute specimens in our study. We also thank the support from Yuzhong District Center for Disease Control and Prevention (Chongqing) and all medical personnels who worked hard in this trial. This study had received funding support from Chongqing Biomedical R & D Major Special Project (No. CSTB2022TIAD-STX0013), Chongqing Science and Health Joint Medical High-end Talent Project (No. 2022GDRC012), Science and Technology Research Program of Chongqing Municipal Education Commission (No. KJZD-K202100402), the Science and Technology Reseearch Program of Chongqing Municipal Education Commission (No. KJQN202200466), CQMU Program for Youth Innovation in Future Medicine (No. W0073)."