Association between serum interleukin-17 levels and ectopic bone formation in OPLL patients with DISH

作者全名："He, Zhongyuan; Tung, Nguyen Tran Canh; Yahara, Yasuhito; Makino, Hiroto; Yasuda, Taketoshi; Seki, Shoji; Suzuki, Kayo; Futakawa, Hayato; Kamei, Katsuhiko; Kawaguchi, Yoshiharu"

作者地址："[He, Zhongyuan; Tung, Nguyen Tran Canh; Makino, Hiroto; Yasuda, Taketoshi; Seki, Shoji; Suzuki, Kayo; Futakawa, Hayato; Kamei, Katsuhiko; Kawaguchi, Yoshiharu] Univ Toyama, Fac Med, Dept Orthopaed Surg, Toyama, Japan; [He, Zhongyuan] Chongqing Med Univ, Dept Orthopaed, Affiliated Hosp 2, Chongqing, Peoples R China; [Tung, Nguyen Tran Canh] Vietnam Mil Med Univ, Dept Trauma & Orthopaed Surg, Hanoi, Vietnam; [Yahara, Yasuhito] Osaka Univ, WPI Immunol Frontier Res Ctr, Suita, Osaka, Japan; [Kawaguchi, Yoshiharu] Univ Toyama, Fac Med, Dept Orthopaed Surg, 2630 Sugitani, Toyama 9300194, Japan"

通信作者："Kawaguchi, Y (通讯作者)，Univ Toyama, Fac Med, Dept Orthopaed Surg, 2630 Sugitani, Toyama 9300194, Japan."

来源：RHEUMATOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001095949600001

JCR分区：Q1

影响因子：4.7

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：interleukin-17; diffuse idiopathic skeletal hyperostosis; ossification of the posterior longitudinal ligament; sacroiliac joint; inflammation

摘要："Objective To investigate the relationship between the severity and morphology of heterotopic ossification in the spinal ligaments including sacroiliac (SI) joints, and serum interleukin-17 (IL-17) levels in patients with ossification of the posterior longitudinal ligament (OPLL) with or without diffuse idiopathic skeletal hyperostosis (DISH), as well as a non-OPLL group.Methods A total of 103 patients with OPLL [DISH (-), n = 50; DISH (+), n = 53] and 53 age- and gender-matched controls were included. The serum levels of IL-17 were analysed, and the severity of ectopic ossification and the morphology of ectopic bone formation were evaluated. The SI joint morphological variations were categorized into four types.Results No significant differences were found in serum IL-17 levels between the OPLL and control groups. However, the DISH (+) group showed higher IL-17 levels than the DISH (-) group, especially in female patients (P = 0.003). Additionally, IL-17 levels were positively correlated with the number of flat vertebral units, this being one of the characteristic DISH ossification types (R2 = 0.199, P = 0.012). IL-17 levels in the type showing bridging osteophyte and bone fusion were significantly higher in the DISH (+) group than in the DISH (-) group.Conclusion The morphological characteristics of paravertebral bone formation in the entire spine, including the SI joint, are likely associated with serum IL-17 levels in OPLL. These findings provide pathological and serological evidence of local inflammation contributing to paravertebral ossification of OPLL patients."

基金机构：We sincerely thank all participants.

基金资助正文：We sincerely thank all participants.