Combi-Elasto Evaluation of the Degree of Liver Fibrosis in Children with Cholestatic Liver Disease

作者全名："Li, Rina; Hu, Caihui; Xu, Fenglin; Zhang, Qi; Zhou, Fazhi; Zheng, Chenpeng; Gao, Yang; Tang, Yi; Chen, Jingyu"

作者地址："[Li, Rina; Hu, Caihui; Xu, Fenglin; Zhou, Fazhi; Gao, Yang; Tang, Yi; Chen, Jingyu] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Ultrasound,Minist Educ,Key Lab Child Dev & Di, Chongqing 400014, Peoples R China; [Zhang, Qi] FUJIFILM Med Syst Guangzhou Co Ltd, Guangzhou 510620, Peoples R China; [Zheng, Chenpeng] Chongqing Emergency Med Ctr, Dept Ultrasound, Chongqing 400016, Peoples R China"

通信作者："Chen, JY (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Ultrasound,Minist Educ,Key Lab Child Dev & Di, Chongqing 400014, Peoples R China."

来源：DIAGNOSTICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001096528300001

JCR分区：Q1

影响因子：3

年份：2023

卷号：13

期号：20

开始页：　

结束页：　

文献类型：Article

关键词：child; cholestatic liver disease; liver fibrosis; combi-elasto

摘要："Cholestatic liver disease is a common liver disease in infants and young children. Liver fibrosis is a key factor affecting the prognosis, and liver transplantation is the only treatment option for liver cirrhosis. This study aimed to explore the efficacy of Combi-elasto for diagnosing liver fibrosis in children affected by cholestatic liver disease. A total of 64 children with S1-S4-grade liver fibrosis were enrolled. The general data, routine ultrasound, Combi-elasto, aspartate aminotransferase-to-platelet ratio index (APRI) and Fibrosis-4 (FIB-4) score were compared among children with different grades of liver fibrosis, and the efficacy of the above indexes for evaluating the degree of liver fibrosis was reported. There were remarkable differences in liver size, liver echogenicity, Young's modulus (E), fibrosis index (FI), activity index (AI) and FIB-4 score among the groups (all p < 0.05). E and liver echogenicity were the independent impact factors of liver fibrosis. The areas under the curve of E, APRI, FIB-4 score and the combined model (E+ liver echogenicity) in the evaluation of liver fibrosis were 0.84, 0.61, 0.66 and 0.90, respectively. Ultimately, we concluded that CE is an effective method to evaluate liver fibrosis in children with cholestatic liver disease."

基金机构："The authors thank FUJIFILM Medical system for their strong support and assistance, including the provision of equipment and personnel."

基金资助正文："The authors thank FUJIFILM Medical system for their strong support and assistance, including the provision of equipment and personnel."