New two-dimensional nanocomposites combined with target-induced strategy in an electrochemical aptasensor for sensitive determination of sulfadimethoxine

作者全名："Yan, Chuanyong; Mu, Zhaode; Wu, Yijie; Liao, Xingxing; Zhou, Jiaxu; Bai, Lijuan"

作者地址："[Yan, Chuanyong] China Univ Min & Technol, Xuzhou Coll Ind Technol, Xuzhou 221000, Jiangsu, Peoples R China; [Mu, Zhaode; Wu, Yijie; Liao, Xingxing; Zhou, Jiaxu; Bai, Lijuan] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China"

通信作者："Bai, LJ (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China."

来源：MICROCHIMICA ACTA

ESI学科分类：CHEMISTRY

WOS号：WOS:001097513100002

JCR分区：Q1

影响因子：5.3

年份：2023

卷号：190

期号：11

开始页：　

结束页：　

文献类型：Article

关键词：Electrochemical detection; Differential pulse voltammetry; Modified electrode; Biosensor; Sulfadimethoxine; NiZn-MOF NSs

摘要："Ni-Zn bimetallic organic framework nanosheets (NiZn-MOF NSs) were modified onto PEI-functionalized MXene for the first time. The combination of the two kinds of nanosheets forms a sensing platform with superior conductivity and biocompatibility. On this basis, a highly sensitive biosensor was developed for the determination of sulfadimethoxine (SDM). Furthermore, Au and Mn nanoparticles decorated reduced graphene oxide (Au-Mn/rGO) was introduced as a signal hindering molecule under the target-induced amplification strategy. When the Au-Mn/rGO-labelled SDM-binding aptamer (Au-Mn/rGO-SBA) specifically bound to target SDM, it detached from the electrode, thereby further amplifying the electrochemical signal of [Fe(CN)6]3-/4-. The developed aptasensor for SDM showed excellent response signals in the range 1 pg mL-1 to 100 ng mL-1, with a limit of detection (LOD) as low as 0.22 pg mL-1. Significantly, the proposed sensor also showed satisfactory results in milk samples with recoveries ranging from 87.0 to 96.4% and RSD from 1.5 to 5.1%, which is believed to be useful in food safety assays."

基金机构："National Natural Science Foundation of China [82072378, 81601856]; Chongqing Talents: Exceptional Young Talents Project, China [CQYC202005015, cstc2021ycjh-bgzxm0328]; Ba Yu Scholar Program, China [YS2019020]; Program for Youth Innovation in Future Medicine, Chongqing Medical University, China [W0067]; Funds for High Level Young Science and Technology Talent Cultivation Plan in Chongqing Medical University, China; Scientific Research and Innovation Experiment Project for College Students at Chongqing Medical University, China [202312]; Discipline Talent Training Program of College of Pharmacy in Chongqing Medical University, China [YXY2019XSGG4]"

基金资助正文："This work is supported by the National Natural Science Foundation of China (82072378, 81601856), Chongqing Talents: Exceptional Young Talents Project, China (CQYC202005015, cstc2021ycjh-bgzxm0328), Ba Yu Scholar Program, China (YS2019020), Program for Youth Innovation in Future Medicine, Chongqing Medical University, China (W0067), Funds for High Level Young Science and Technology Talent Cultivation Plan in Chongqing Medical University, China (2019), Scientific Research and Innovation Experiment Project for College Students at Chongqing Medical University, China (202312) and Discipline Talent Training Program of College of Pharmacy in Chongqing Medical University, China (YXY2019XSGG4)"