Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review

作者全名："Wang, Kaiyang; Zhang, Huhai; Yuan, Lie; Li, Xiaoli; Cai, Yongqing"

作者地址："[Wang, Kaiyang; Cai, Yongqing] Army Med Univ, Daping Hosp, Dept Pharm, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China; [Zhang, Huhai] Army Med Univ, Southwest Hosp, Dept Nephrol, Chongqing, Peoples R China; [Yuan, Lie; Li, Xiaoli] Chongqing Med Univ, Coll Pharm, Dept Pharmacol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Yuan, Lie; Li, Xiaoli] Chongqing Med Univ, Coll Pharm, Chongqing Key Res Lab Drug Metab, Chongqing, Peoples R China"

通信作者："Cai, YQ (通讯作者)，Army Med Univ, Daping Hosp, Dept Pharm, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China.; Li, XL (通讯作者)，Chongqing Med Univ, Coll Pharm, Dept Pharmacol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF INFLAMMATION RESEARCH

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001099357800001

JCR分区：Q2

影响因子：4.2

年份：2023

卷号：16

期号：　

开始页：4503

结束页：4526

文献类型：Review

关键词：hyperoside; original plant; chemical structure; pharmacology; pharmacokinetics; toxicity

摘要："Hyperoside is a flavonol glycoside mainly found in plants of the genera Hypericum and Crataegus, and also detected in many plant species such as Abelmoschus manihot, Ribes nigrum, Rosa rugosa, Agrostis stolonifera, Apocynum venetum and Nelumbo nucifera. This compound exhibits a multitude of biological functions including anti-inflammatory, antidepressant, antioxidative, vascular protective effects and neuroprotective effects, etc. This review summarizes the quantification, original plant, chemical structure and property, structure-activity relationship, pharmacologic effect, pharmacokinetics, toxicity and clinical application of hyperoside, which will be significant for the exploitation for new drug and full utilization of this compound."

基金机构："Chongqing Clinical Pharmacy Key Specialties Construction Project, Technology Project of Chongqing Health and Family Planning Commission [2019MSXM010]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0223]"

基金资助正文："Funding This project is supported by a grant from the Chongqing Clinical Pharmacy Key Specialties Construction Project, Technology Project of Chongqing Health and Family Planning Commission (2019MSXM010) and Natural Science Foundation of Chongqing (No. cstc2020jcyj-msxmX0223) ."