Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment

作者全名："Zhou, Li; Bai, Xue; Huang, Jiagui; Tan, Yongjun; Yang, Qin"

作者地址："[Zhou, Li; Huang, Jiagui; Tan, Yongjun; Yang, Qin] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Bai, Xue] First Peoples Hosp, Dept Neurol, Neijiang, Sichuan, Peoples R China; [Yang, Qin] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Yang, Q (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：NUTRICION HOSPITALARIA

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001099729300030

JCR分区：Q4

影响因子：1.2

年份：2023

卷号：40

期号：4

开始页：724

结束页：731

文献类型：Article

关键词：Vitamin B12. Cobalamin.; Cognitive impairment.; Middle aged and elderly.; Frontal function.

摘要："Objectives: to determine the effects of vitamin B12 supplementation on neuropsychological function and disease progression in middle aged and elderly patients with cognitive impairment.Methods: this was a prospective case-control study. From May 2020 to May 2021, 307 participants clinically diagnosed with cognitive impair-ment in the Department of Neurology of the First Affiliated Hospital of Chongqing Medical University were enrolled. A total of 115 patients were included in this study. Meanwhile, 115 participants with cognitive impairment were randomly assigned in equal proportions to two groups: vitamin B12 treatment group (n = 58, vitamin B12 500 mg/d intramuscularly for seven days, followed by cobamamide 0.25 mg/d and methylcobalamin 0.50 mg/d) and the control group (n = 57). Demographic characteristics and blood biochemical variables were obtained from all participants. Cognitive performance was measured using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Cognitive performance was measured at baseline and after six months.Results: the vitamin B12 supplementation treatment patients who presented with cognitive impairment showed significant improvement, especially in attention, calculation (p < 0.01) and visual-constructional ability (p < 0.05), in their neuropsychological function compared to their matched group.Conclusion: vitamin B12 supplementation may improve frontal function in patients with cognitive decline. Vitamin B12 levels should be inves-tigated in all patients with cognitive impairment."

基金机构："National Natural Science Foundation of China [82171456, 81971229]; Natural Science Foundation of Chongqing Science and Technology Commission [cstc2021jcyj-msxmX0263]"

基金资助正文：Acknowledgments: this work was supported by grants from the National Natural Science Foundation of China (grant no. 82171456 and 81971229) and the Natural Science Foundation of Chongqing Science and Technology Commission (grant no. cstc2021jcyj-msxmX0263) .