Bioactive coating with antibacterial and anticorrosive properties deposited on ZA6-1 alloy bone implant

作者全名："Zhao, De-ren; Chen, Dong; Feng, Xue; Chen, Zi-lin; Jin, Chen; Tan, Xiao-dong; Xiang, Yun-jie; Jiao, Wen-bo; Fang, Ya-xing; Xu, Li-qun; Zhang, Yong-ping; Rao, Xi"

作者地址："[Zhao, De-ren; Chen, Zi-lin; Jin, Chen; Tan, Xiao-dong; Xiang, Yun-jie; Jiao, Wen-bo; Fang, Ya-xing; Xu, Li-qun; Zhang, Yong-ping; Rao, Xi] Southwest Univ, Sch Mat & Energy, Chongqing 400715, Peoples R China; [Zhao, De-ren; Chen, Zi-lin; Jin, Chen; Tan, Xiao-dong; Xiang, Yun-jie; Jiao, Wen-bo; Fang, Ya-xing; Xu, Li-qun; Zhang, Yong-ping; Rao, Xi] Southwest Univ, Chongqing Key Lab Soft Matter Mat Chem & Funct Mfg, Chongqing 400715, Peoples R China; [Chen, Dong] Southwest Univ, Sch Food Sci, Chongqing 400715, Peoples R China; [Feng, Xue] Chongqing Med Univ, Univ Town Hosp, Dept Clin Lab, Chongqing 401331, Peoples R China"

通信作者："Zhang, YP; Rao, X (通讯作者)，Southwest Univ, Sch Mat & Energy, Chongqing 400715, Peoples R China.; Zhang, YP; Rao, X (通讯作者)，Southwest Univ, Chongqing Key Lab Soft Matter Mat Chem & Funct Mfg, Chongqing 400715, Peoples R China."

来源：TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001100668400001

JCR分区：Q1

影响因子：4.7

年份：2023

卷号：33

期号：5

开始页：1507

结束页：1521

文献类型：Article

关键词：zinc alloy; polymer coating; antibacterial property; biocompatibility; corrosion behavior

摘要："The commercial zinc aluminum alloy (ZA6-1) surface was functionalized with poly-(lactic-co-glycolic) acid (PLGA) containing sodium dodecyl sulfate (SDS) and levulinic acid (LA) for gaining antibacterial activity. A polymerized 3-aminopropyltriethoxysilane (APTES) layer was initially fabricated on the surface of ZA6-1 alloy to gain amino group, and the PLGA mixed with SDS/LA was subsequently immobilized on the as-treated surface through the electrostatic interaction between amino group and carboxyl group. The PLGA-SDS/LA coating on zinc alloy showed extremely good corrosion resistance with the degradation rate of 0.005 mm/a, which can be adjusted by varying the coating thickness. Furthermore, besides the good biocompatibility to osteoblasts, the PLGA-SDS/LA coating exhibited excellent antibacterial property, and the bactericidal rates against Staphylococcus aureus and Escherichia coli were 98.9% and 99.8%, respectively."

基金机构："National Natural Science Foundation of China [51801164]; Fundamental Research Funds for the Central Universities, China [XDJK2020C005]; Chongqing Key Laboratory Fund of Soft-matter Material Chemistry and Function Manufacturing, China [20200006]; Chongqing College Student Innovation and Entrepreneurship Program of Southwest University, China [202010635076]"

基金资助正文："The authors acknowledge supports from National Natural Science Foundation of China (No. 51801164) , the Fundamental Research Funds for the Central Universities, China (No. XDJK2020C005) , Chongqing Key Laboratory Fund of Soft-matter Material Chemistry and Function Manufacturing, China (No. 20200006) , and Chongqing College Student Innovation and Entrepreneurship Program of Southwest University, China (No. 202010635076) ."