Risky working conditions and chronic kidney disease

作者全名："Lan, Rui; Qin, Yao; Chen, Xiangjun; Hu, Jinbo; Luo, Wenjin; Shen, Yan; Li, Xue; Mao, Lina; Ye, Hanwen; Wang, Zhihong"

作者地址："[Lan, Rui; Qin, Yao; Chen, Xiangjun; Hu, Jinbo; Luo, Wenjin; Shen, Yan; Li, Xue; Mao, Lina; Ye, Hanwen; Wang, Zhihong] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, 1 Youyi St, Chongqing 400016, Peoples R China"

通信作者："Wang, ZH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, 1 Youyi St, Chongqing 400016, Peoples R China."

来源：JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001101274200002

JCR分区：Q2

影响因子：2.9

年份：2023

卷号：18

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Occupational; Chronic kidney disease; Work environments

摘要："BackgroundIndividuals in the workplace are exposed to various environments, tasks, and schedules. Previous studies have indicated a link between occupational exposures and an increased risk of chronic kidney disease (CKD). However, the social conditions of the work environment may also be a crucial contributing factor to CKD. Furthermore, individuals may encounter multiple occupational-related risk factors simultaneously, underscoring the importance of investigating the joint risk of different working conditions on CKD.MethodsA prospective analysis of 65,069 UK Biobank participants aged 40 to 69 years without CKD at baseline (2006-2010) was performed. A self-administered questionnaire assessed working conditions and a working conditions risk score were developed. Participants who answered ""sometimes"" or ""often"" exposure to occupational heat or occupational secondhand cigarette smoke; involved in shift work or heavy workloads (""usually"" or ""always""), were grouped as high-risk working conditions. Each working condition was scored as 1 if grouped as high-risk, and 0 if not. The working conditions risk score was equal to the sum of these four working conditions. Cox proportional hazard regression models were used to estimate the associations between working conditions and CKD incidence.ResultsThe mean follow-up time was 6.7 years. After adjusting for demographic, lifestyle, and working time factors, the hazard ratios for the development of CKD for heavy workloads, shift work, occupational secondhand cigarette smoke exposure, and occupational heat exposure were 1.24 (95%CI = 1.03, 1.51), 1.33 (95%CI = 1.10, 1.62), 1.13 (95%CI = 1.01, 1.26), 1.11 (95%CI = 0.99, 1.24), respectively. The risk of CKD was found to be significantly associated with an increasing working conditions risk score. Individuals with a working conditions risk score of 4 had an 88.0% (95% CI = 1.05, 3.35) higher risk of developing CKD when compared to those with a working conditions risk score of 0.ConclusionsAdverse working conditions, particularly when considered in combination, can significantly elevate the risk of chronic kidney disease (CKD). These results provide a reference for implementing measures to prevent CKD."

基金机构：The authors would like to acknowledge UK Biobank for their participation and contribution to the research.

基金资助正文：The authors would like to acknowledge UK Biobank for their participation and contribution to the research.