The role of non-canonical Hippo pathway in regulating immune homeostasis

作者全名："Tang, Dagang; Xu, Huan; Du, Xing"

作者地址："[Tang, Dagang] Chongqing Tradit Chinese Med Hosp, Dept Orthoped, Chongqing 400021, Peoples R China; [Xu, Huan] Army Med Univ, Daping Hosp, Dept Ophtalmol, Chongqing 400012, Peoples R China; [Du, Xing] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, 1 YouYi Rd, Chongqing 400016, Peoples R China; [Du, Xing] Chongqing Med Univ, Orthoped Lab, Chongqing 400016, Peoples R China"

通信作者："Du, X (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, 1 YouYi Rd, Chongqing 400016, Peoples R China.; Du, X (通讯作者)，Chongqing Med Univ, Orthoped Lab, Chongqing 400016, Peoples R China."

来源：EUROPEAN JOURNAL OF MEDICAL RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001102061300002

JCR分区：Q2

影响因子：2.8

年份：2023

卷号：28

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Hippo pathway; Immune homeostasis; Macrophages; Oxidative stress; T-cell differentiation

摘要："The Hippo pathway is a crucial signaling pathway that is highly conserved throughout evolution for the regulation of organ size and maintenance of tissue homeostasis. Initial studies have primarily focused on the canonical Hippo pathway, which governs organ development, tissue regeneration, and tumorigenesis. In recent years, extensive research has revealed that the non-canonical Hippo pathway, centered around Mst1/2 as its core molecule, plays a pivotal role in immune response and function by synergistically interacting with other signal transduction pathways. Consequently, the non-canonical Hippo pathway assumes significant importance in maintaining immune system homeostasis. This review concentrates on the research progress of the non-canonical Hippo pathway in regulating innate immune cell anti-infection responses, maintaining redox homeostasis, responding to microenvironmental stiffness, and T-cell differentiation."

基金机构：Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0972]

基金资助正文：This study was funded by the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0972).