The Potential Predicting Value of D-dimer to Fibrinogen Ratio on Functional Outcome at 1 year after Acute Ischemic Stroke : A longitudinal study

作者全名："Lin, Qingxia; Zhou, Dongdong; Cheng, Yifan; Wu, Chunxue; Deng, Binbin"

作者地址："[Lin, Qingxia] Wenzhou Med Univ, Affiliated Hosp 1, Dept Psychiat, Wenzhou 325003, Zhejiang, Peoples R China; [Zhou, Dongdong] Chongqing Med Univ, Univ Town Hosp, Mental Hlth Ctr, Chongqing, Peoples R China; [Cheng, Yifan] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Dept Neurol, Hangzhou, Zhejiang, Peoples R China; [Wu, Chunxue] Wencheng Cty Peoples Hosp, Dept Neurol, Wenzhou 325003, Zhejiang, Peoples R China; [Deng, Binbin] Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325003, Zhejiang, Peoples R China"

通信作者："Deng, BB (通讯作者)，Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325003, Zhejiang, Peoples R China."

来源：GERONTOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001102688100001

JCR分区：Q3

影响因子：3.1

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Acute ischemic stroke; D-dimer; D-dimer to fibrinogen ratio; Outcome; Modified Rankin scale

摘要："Introduction: Previous studies have suggested that the D-dimer to fibrinogen ratio (DD/Fg) could be a potential predictor for deep vein thrombosis, pulmonary embolism, and stroke severity. However, the association between plasma DD/Fg and functional outcome following acute ischemic stroke (AIS) has been unclear. Methods: Our study followed the STROBE guideline and used a prospective cohort design to investigate this association. A total of 454 patients with AIS were enrolled consecutively in our study, and the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) were assessed for stroke severity and functional outcome, respectively. Results:We found a significant difference in DD/Fg values between the three groups based on NIHSS scores at admission. Specifically, the DD/Fg values were higher in the poor functional outcome group (mRS score of 2-6) compared to the favorable functional outcome group (mRS score of 0-1) at the 1-year follow-up (P < 0.001). Additionally, the DD/Fg values were independently associated with poor functional prognosis at 1 year following the onset of stroke, even after adjusting for potential confounders (OR 9.21, 95% CI, 3.68-23.02, P<0.001). Conclusions: Our findings suggest that DD/Fg values at admission may serve as risk predictors for poor functional outcomes in patients with AIS 1 year after the stroke."

基金机构：National Natural Science Foundation of China [81901273]; Science Technology Department of Zhejiang Province [Q21H090076]

基金资助正文："This work was supported by the National Natural Science Foundation of China (Grant number 81901273) and Science Technology Department of Zhejiang Province (Grant number Q21H090076). The funders had no role in study design, data collection, and analysis, decision to publish, or reparation of the manuscript."