The pentraxin family in autoimmune disease

作者全名："Li, Yongzhen; Zhang, Shouzan; Liu, Jingqi; Zhang, Yudi; Zhang, Nan; Cheng, Quan; Zhang, Hao; Wu, Xiaochuan"

作者地址："[Li, Yongzhen; Liu, Jingqi; Zhang, Yudi; Wu, Xiaochuan] Cent South Univ, Xiangya Hosp 2, Dept Pediat, Changsha, Hunan, Peoples R China; [Zhang, Shouzan] Peking Univ Third Hosp, Dept Neurosurg, Beijing, Peoples R China; [Zhang, Nan] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan, Hubei, Peoples R China; [Cheng, Quan] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China; [Cheng, Quan] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China; [Zhang, Hao] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China"

通信作者："Wu, XC (通讯作者)，Cent South Univ, Xiangya Hosp 2, Dept Pediat, Changsha, Hunan, Peoples R China.; Cheng, Q (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China.; Zhang, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China."

来源：CLINICA CHIMICA ACTA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001102703700001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：551

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：The Pentraxin Family; Autoimmunity diseases; Inflammation; Immunity; Tissue remodeling; CRP; PTX3

摘要："The pentraxins represent a family of multifunctional proteins composed of long and short pentamers. The latter includes serum amyloid P component (SAP) and C-reactive protein (CRP) whereas the former includes neuronal PTX1 and PTX2 (NPTX1 and NPTX2, respectively), PTX3 and PTX4. These serve as a bridge between adaptive immunity and innate immunity and a link between inflammation and immunity. Similarities and differences between long and short pentamers are examined and their roles in autoimmune disease are discussed. Increased CRP and PTX3 could indicate the activity of rheumatoid arthritis, systemic lupus erythematosus or other autoimmune diseases. Mechanistically, CRP and PTX3 may predict target organ injury, regulate bone metabolic immunity and maintain homeostasis as well as participate in vascular endothelial remodeling. Interestingly, PTX3 is pleiotropic, being involved in inflammation and tissue repair. Given the therapeutic potential of PTX3 and CRP, targeting these factors to exert a beneficial effect is the focus of research efforts. Unfortunately, studies on NPTX1, NPTX2, PTX4 and SAP are scarce and more research is clearly needed to elaborate their potential roles in autoimmune disease."

基金机构：national key RD Project [2021YFC2702004]; Hunan Provincial Health Committee Foundation of China [B202306017169]; Changsha Natural Science Foundation [kq2208314]

基金资助正文：This work was supported by the national key R & D Project (no.2021YFC2702004). Hunan Provincial Health Committee Foundation of China (no. B202306017169). Changsha Natural Science Foundation (no. kq2208314).