Thrombospondin 2 is a novel biomarker of essential hypertension and associated with nocturnal Na<SUP>+</SUP> excretion and insulin resistance

作者全名："Zhou, Xiaoxin; Zhang, Longlong; Lin, Xiaoqian; Chen, Xi; Liu, Hong; Yuan, Xiaoli; Zhao, Qiuxia; Wang, Weiwei; Lei, Xun; Jose, Pedro A.; Deng, Chunyan; Yang, Jian"

作者地址："[Zhou, Xiaoxin; Zhang, Longlong; Lin, Xiaoqian; Chen, Xi; Liu, Hong; Wang, Weiwei; Deng, Chunyan; Yang, Jian] Chongqing Med Univ, Res Ctr Metab & Cardiovasc Dis, Affiliated Hosp 3, Chongqing, Peoples R China; [Zhou, Xiaoxin; Zhang, Longlong; Lin, Xiaoqian; Chen, Xi; Liu, Hong; Yang, Jian] Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 3, Chongqing, Peoples R China; [Zhang, Longlong] Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 3, Chongqing, Peoples R China; [Yuan, Xiaoli; Zhao, Qiuxia] Chongqing Med Univ, Hlth Management Ctr, Affiliated Hosp 3, Chongqing, Peoples R China; [Wang, Weiwei] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 3, Chongqing, Peoples R China; [Lei, Xun] Chongqing Med Univ, Res Ctr Med & Social Dev, Collaborat Innovat Ctr Social Risks Governance Hlt, Sch Publ Hlth, Chongqing, Peoples R China; [Jose, Pedro A.] George Washington Univ, Dept Med, Div Renal Dis & Hypertens, Sch Med & Hlth Sci, New York City, WA USA; [Jose, Pedro A.] George Washington Univ, Dept Physiol & Pharmacol, Sch Med & Hlth Sci, New York City, WA USA; [Deng, Chunyan] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 3, Chongqing, Peoples R China"

通信作者："Deng, CY; Yang, J (通讯作者)，Chongqing Med Univ, Res Ctr Metab & Cardiovasc Dis, Affiliated Hosp 3, Chongqing, Peoples R China."

来源：CLINICAL AND EXPERIMENTAL HYPERTENSION

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001103142600001

JCR分区：Q3

影响因子：1.5

年份：2023

卷号：45

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Thrombospondin 2; hypertension; renal Na+ excretion; insulin resistance; endothelial function

摘要："Background Thrombospondins (TSPs) play important roles in several cardiovascular diseases. However, the association between circulating (plasma) thrombospondin 2 (TSP2) and essential hypertension remains unclear. The present study was aimed to investigate the association of circulating TSP2 with blood pressure and nocturnal urine Na+ excretion and evaluate the predictive value of circulating TSP2 in subjects with hypertension.Methods and Results 603 newly diagnosed essential hypertensive subjects and 508 healthy subjects were preliminarily screened, 47 healthy subjects and 40 newly diagnosed essential hypertensive subjects without any chronic diseases were recruited. The results showed that the levels of circulating TSP2 were elevated in essential hypertensive subjects. The levels of TSP2 positively associated with systolic blood pressure (SBP), diastolic blood pressure (DBP), and other clinical parameters, including homeostasis model assessment of insulin resistance (HOMA-IR), brachial-ankle pulse wave velocity, and serum triglycerides, but negatively associated with nocturnal urine Na+ concentration and excretion and high-density lipoprotein cholesterol. Results of multiple linear regressions showed that HOMA-IR and nocturnal Na+ excretion were independent factors related to circulating TSP2. Mantel-Haenszel chi-square test displayed linear relationships between TSP2 and SBP (chi(2) = 35.737) and DBP (chi(2) = 26.652). The area under receiver operating characteristic curve (AUROC) of hypertension prediction was 0.901.Conclusion Our study suggests for the first time that the circulating levels of TSP2 may be a novel potential biomarker for essential hypertension. The association between TSP2 and blood pressure may be, at least in part, related to the regulation of renal Na+ excretion, insulin resistance, and/or endothelial function. GRAPHICAL ABSTRACT"

基金机构：National Natural Science Foundation of China [82100459]; Scientific Research Innovation Project for Postgraduate in Chongqing [CYB22227]; Program of Chongqing Medical University for Youth Innovation in Future Medicine [W0085]; Project of Chongqing Medical Talent Studio (2022)

基金资助正文："This work was supported in part by grants from the National Natural Science Foundation of China (82100459), the Scientific Research Innovation Project for Postgraduate in Chongqing (CYB22227), Program of Chongqing Medical University for Youth Innovation in Future Medicine (W0085), and Project of Chongqing Medical Talent Studio (2022)."