Antimicrobial poly(aspartic acid) based self-healing hydrogel with enhance cell migration rate for burn wound treatment

作者全名："Chen, Yanai; Chang, Limin; Zhu, Jingjing; Sun, Weichen; Wang, Yong; Li, Wenjuan; Liu, Yanfang; Yu, Xian; Qin, Jianglei"

作者地址："[Chen, Yanai; Chang, Limin; Sun, Weichen; Liu, Yanfang; Qin, Jianglei] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Hebei, Peoples R China; [Wang, Yong; Li, Wenjuan; Qin, Jianglei] Hebei Univ, Key Lab Pathogenesis Mech & Control Inflammatory A, Baoding 071002, Hebei, Peoples R China; [Yu, Xian] Chongqing Med Univ, Affiliated Hosp 2, Clin Trial Ctr Phase 1, Chongqing, Peoples R China; [Zhu, Jingjing] Hebei Univ, Baoding, Peoples R China"

通信作者："Qin, JL (通讯作者)，Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Hebei, Peoples R China.; Yu, X (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Clin Trial Ctr Phase 1, Chongqing, Peoples R China."

来源：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001104108400001

JCR分区：Q1

影响因子：4.5

年份：2023

卷号：89

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Poly(aspartic acid) Self-healing hydrogel Antibacterial Burn wound healing

摘要："Bacterial infection of the trauma can cause the wound decay to slow down the healing process and worsen the patient's condition. Recently, the treatment of infected wounds with hydrogels has received great attentions in the development of wound dressings. In this research, the poly (aspartic acid) (PAsp) with hydrazide functional groups (PAH) was hydrazinolyzed from poly (succinimide) (PSI) and cross-linked with dialdehyde functionalized PEO to prepare self-healing hydrogels for bacterial infection prone burn wound treatment. In addition, the antibacterial quaternary ammonium moiety and the aniline tetramer (AT) were imported to the PAH to enhance the antibacterial property and reactive oxygen species (ROS) scavenging activity of the hydrogel to accelerate burn wound repairing rate. The functionalized hydrogel showed expected antibacterial property with good biocompatibility well preserved. The in vivo burn wound repairing experiment indicated this antibacterial hydrogel enhance the burn wound repairing performance and could be used as infectious wound dressing."

基金机构："National Natural Science Foundation of China [82072327]; State Key Laboratory of New Pharmaceutical Preparations and Excipients, Natural Science Interdisciplinary Research Program of Hebei University [DXK202202]; Medical Science Foundation of Hebei University [2021A01, 2021X01]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (82072327) , State Key Laboratory of New Pharmaceutical Preparations and Excipients, Natural Science Interdisciplinary Research Program of Hebei University (DXK202202) , Medical Science Foundation of Hebei University (2021A01, 2021X01) ."