Left atrial appendage closure for stroke prevention in atrial fibrillation patients: A promise that came true

作者全名："Jiang, Xi; Xiong, Qingsong; Yin, Yuehui; Ling, Zhiyu"

作者地址："[Jiang, Xi; Xiong, Qingsong; Yin, Yuehui; Ling, Zhiyu] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing, Peoples R China; [Ling, Zhiyu] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing 400010, Peoples R China"

通信作者："Ling, ZY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing 400010, Peoples R China."

来源：PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001104899900001

JCR分区：Q3

影响因子：1.8

年份：2023

卷号：46

期号：12

开始页：1576

结束页：1585

文献类型：Review; Early Access

关键词：antithrombotic therapy; atrial fibrillation; left atrial appendage closure; left atrial appendage occlusion; stroke prevention

摘要："Anticoagulation therapy plays a crucial role in the management of atrial fibrillation (AF), considering the high morbidity and mortality of AF-related ischemic strokes. With the plausible hypothesis that left atrial appendage is the main source of thrombus in AF patients, left atrial appendage closure (LAAC) has been regarded as a potential substitute to oral anticoagulation in order to meet the unmet needs for stroke prevention, particularly in patients with high bleeding risk. Notable advancements in safety, efficacy, and device innovation have been made in recent years, albeit concerns still remain regarding the insufficient efficacy data, device-related complications, and the need for procedural optimization. We aim to review current knowledge about LAAC and provide potential future directions for the remaining key issues."

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