"Age-related differences in risk factors, clinical characteristics, and outcomes for intracerebral hemorrhage"

作者全名："Chen, Chu; Xie, Yanfang; Pu, Mingjun; Deng, Lan; Li, Zuoqiao; Yang, Tiannan; Yin, Hao; Zhang, Zhehao; Lv, Xinni; Liu, Xueyun; Cheng, Jing; Li, Qi"

作者地址："[Chen, Chu; Pu, Mingjun; Deng, Lan; Li, Zuoqiao; Yang, Tiannan; Yin, Hao; Zhang, Zhehao; Lv, Xinni; Li, Qi] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Xie, Yanfang; Liu, Xueyun] Anhui Med Univ, Dept Neurol, Affiliated Hosp 2, Hefei, Anhui, Peoples R China; [Cheng, Jing] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 3, Chongqing, Peoples R China"

通信作者："Li, Q (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN AGING NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001105247300001

JCR分区：Q2

影响因子：4.1

年份：2023

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：intracerebral hemorrhage; outcome; predictor; risk factor; young patients

摘要："Background and purpose: Intracerebral hemorrhage (ICH) is a severe form of stroke that remains understudied in the young adults. We aimed to investigate the clinical presentation, and risk factors associated with ICH in this age group and compare them to older patients.Methods: Our study included ICH patients admitted between March 2016 and December 2021 in the First Affiliated Hospital of Chongqing Medical University from our ongoing prospective cohort database. Demographic characteristics, etiology, risk factors, and clinical outcomes were compared between elderly and young patients. Furthermore, logistic regression analysis was employed to explore risk factors associated with the functional outcome at 3-months.Results: We selected 1,003 patients (mean age, 59.9 +/- 13.8 years old), 746 (74.4%) patients were aged >50 years. The logistic regression analysis showed young patients have a higher proportion of secondary ICH, higher white blood cell count and higher body mass index (BMI), but less diabetes mellitus. Of all patients, predictors of 3-month functional independence was first-ever ICH and age <= 50 years. The history of nephropathy and stroke, higher baseline NIHSS score, larger hematoma volume, and the presence of hydrocephalus were associated with poor outcomes. And the white blood cell count could significantly influence the prognosis among young ICH patients. Three-month functional outcome based on modified Rankin scale score was better in young patients than the elderly (OR, 1.232; 95% CI, 1.095-1.388; p < 0.001).Conclusions: The highest incidence of ICH occurs in the age groups of 50-59 and 60-69. ICH in young adults had higher white blood cell and BMI compared to the elderly, and differs in etiological distribution. The young patients also had similar short-term mortality but more favorable functional outcomes than the elderly. Furthermore, NIHSS score and larger hematoma volumes were associated with poor outcome in all patients."

基金机构："The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the National Natural Science Foundation of China (grant no. 82071337), the Chongqing Innovation Support Progr [82071337]; National Natural Science Foundation of China [cx2020002]; Chongqing Innovation Support Program for Returned Overseas Chinese Scholars [cstc2021jcyj-jqX0029]; Chongqing Science Fund for Distinguished Young Scholars [2022zhyx-C38]; Research Fund of Anhui Institute of Translational Medicine"

基金资助正文："The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the National Natural Science Foundation of China (grant no. 82071337), the Chongqing Innovation Support Program for Returned Overseas Chinese Scholars (grant no. cx2020002), the Chongqing Science Fund for Distinguished Young Scholars (grant no. cstc2021jcyj-jqX0029), and Research Fund of Anhui Institute of Translational Medicine (grant no. 2022zhyx-C38)."