Preparation of bacterial cellulose-based antibacterial membranes with prolonged release of drugs: Emphasis on the chemical structure of drugs

作者全名："Ye, Jianbin; Li, Jianqing; Wang, Xiangjiang; Wang, Qiuhui; Wang, Shouan; Wang, Honglin; Zhu, Hu; Xu, Jia"

作者地址："[Ye, Jianbin; Li, Jianqing; Wang, Qiuhui] Fujian Med Univ, Sch Pharm, Fuzhou City 350004, Fujian Province, Peoples R China; [Ye, Jianbin; Li, Jianqing; Wang, Xiangjiang; Wang, Qiuhui; Wang, Shouan; Xu, Jia] Putian Univ, Sch Basic Med Sci, Key Lab Translat Tumor Med Fujian Prov, Putian City 351100, Fujian Province, Peoples R China; [Wang, Honglin] Chongqing Med Univ, Dept Orthoped Surg, Dazu Hosp, Chongqing 402360, Peoples R China; [Zhu, Hu] Fujian Normal Univ, Coll Chem & Mat Sci, Engn Res Ctr Ind Biocatalysis, Fujian Taiwan Sci & Technol Cooperat Base Biomed M, Fuzhou 350007, Peoples R China; [Xu, Jia] Putian Univ, Sch Basic Med Sci, Putian, Peoples R China"

通信作者："Wang, HL (通讯作者)，Chongqing Med Univ, Dept Orthoped Surg, Dazu Hosp, Chongqing 402360, Peoples R China.; Zhu, H (通讯作者)，Fujian Normal Univ, Coll Chem & Mat Sci, Engn Res Ctr Ind Biocatalysis, Fujian Taiwan Sci & Technol Cooperat Base Biomed M, Fuzhou 350007, Peoples R China.; Xu, J (通讯作者)，Putian Univ, Sch Basic Med Sci, Putian, Peoples R China."

来源：CARBOHYDRATE POLYMERS

ESI学科分类：CHEMISTRY

WOS号：WOS:001106017800001

JCR分区：Q1

影响因子：11.2

年份：2024

卷号：323

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Bacterial cellulose; Cefoperazone; Nanocomposites; Biomaterial; Carboxly; Nanofibers

摘要："Bacterial cellulose (BC) based antibacterial membranes were synthesized, including BC-cefoperazone (BC-CEF) and BC-cefoperazone sodium (BC-CEF/Na). To examine the various drug loading processes, the structure, morphology, and physical-chemical characteristics of membranes were evaluated. Results demonstrated that both types of medicines were successfully absorbed into membranes, and membranes displayed identical morphology and FT-IR peaks. BC-CEF showed lower crystalline of XRD, which was likely caused by the com-bination of carboxyl and hydroxyl. However, there were no drug peaks seen in the membranes, indicating no alteration of ribbon crystallization of BC. Two types of antibacterial membranes have significantly distinct drug -loading traits and drug-releasing profiles. The drug loading rate of CEF (46.4 mg/g) was significantly greater than CEF/Na (30.3 mg/g). The cumulative drug-releasing profiles showed that only BC-CEF continues to release drugs for a lengthy period up to 48 h and exhibited good antimicrobial activity against S. aureus and E. coli until 48 h. The cytotoxicity assay demonstrated the great biocompatibility of all membranes. Findings indicated that BC-CEF has the potential use as a prolonged biocide in the biomedical. The idea that BC membranes can naturally incorporate the carboxyl groups from antibiotics is also innovative and can be useful in developing of drug delivery systems."

基金机构："Doctor Support Grants of Putian University [2021068, 2021069]; Science and Techonoly Project of Putian City [2022SZ3001ptxy08, 2022SZ3001ptxy09]; Natural Science Foundation of Fujian Province [2021J05242, 2021J05241, 2022J011167]"

基金资助正文："The work was partly supported by the Doctor Support Grants of Putian University (2021068, 2021069) , Science and Techonoly Project of Putian City (2022SZ3001ptxy08, 2022SZ3001ptxy09) and the Nat- ural Science Foundation of Fujian Province (2021J05242, 2021J05241, 2022J011167) ."