The clinical signification and application value of [<SUP>68</SUP>Ga]Ga-PSMA imaging in thyroid malignancy

作者全名："Feng, Yu Yue; Shi, Yang Rui; Xia, Zhu; Xu, Lu; Li, Wen Bo; Pang, Hua; Wang, Zheng jie"

作者地址："[Feng, Yu Yue; Shi, Yang Rui; Xia, Zhu; Xu, Lu; Li, Wen Bo; Pang, Hua; Wang, Zheng jie] Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, 1 Youyi Rd, Chongqing, Peoples R China"

通信作者："Pang, H; Wang, ZJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Nucl Med, 1 Youyi Rd, Chongqing, Peoples R China."

来源：ENDOCRINE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001106092100002

JCR分区：Q2

影响因子：3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Prostate-specific membrane antigen; Thyroid cancer; Tumor burden

摘要："Purpose Approximately 5% of differentiated thyroid cancers lose the ability to uptake iodine, leading to limited treatment options and poor prognosis due to invasion and distant metastasis. PSMA imaging probes have been proposed as a potential diagnostic and therapeutic tool for iodine-refractory thyroid cancer. However, there are limited reports and significant heterogeneity in patient selection, warranting further exploration of the application value of PSMA in thyroid cancer.Methods We performed Western Blot, PCR, and [Ga-68]Ga-PSMA uptake experiments on cell lines and conducted in vivo small animal imaging. Clinical and radiological results of included differentiated thyroid cancer patients were collected. (Trial registration number: 2021-669, Trial registration date: December 30, 2021).Results PSMA expression levels were significantly higher in poorly differentiated thyroid cancer (7.86 +/- 1.90 vs. 1.00 +/- 0, P < 0.01; 7.86 +/- 1.90 vs. 0.03 +/- 0.02, P < 0.01), but [Ga-68]Ga-PSMA imaging correlated with tumor burden, such as 18F-FDG (8.08 +/- 7.74 and 5.67 +/- 4.23, P = 0.01) and Tg levels (307.1 +/- 183.4 vs. 118.0 +/- 116.1, P = 0.002).Conclusion Our results showed that PSMA expression increased with the decrease of thyroid cancer differentiation. However, the level of [Ga-68]Ga-PSMA uptake in thyroid cancer patients was not significantly associated with the degree of thyroid cancer differentiation, but also with the metabolism and burden of tumors such as 2-[F-18]FDG and Tg levels. These findings provide additional clinical significance and application value for PSMA in thyroid cancer."

基金机构：National Natural Science Foundation of China [82102093]; Natural Science Foundation of Chongqing Municipality [cstc2020jcyj-msxmX0713]; Scientific research project of Chongqing Medical University [11]

基金资助正文："This work was supported by the National Natural Science Foundation of China (Project No.82102093), the Natural Science Foundation of Chongqing Municipality (Project No. cstc2020jcyj-msxmX0713), and the scientific research project of Chongqing Medical University (Project No.11)"