Batroxobin can improve the efficacy of combination therapy for profound sudden sensorineural hearing loss greater than but not less than 100 dB HL

作者全名："Jiang, Li Zhu; Zuo, Wen Qi"

作者地址："[Jiang, Li Zhu; Zuo, Wen Qi] Chongqing Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Chongqing, Peoples R China"

通信作者："Zuo, WQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Otolaryngol, Chongqing, Peoples R China."

来源：JOURNAL OF LARYNGOLOGY AND OTOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001106427500001

JCR分区：Q3

影响因子：1.1

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Batroxobin; sudden deafness; sensorineural hearing loss; therapy; prognosis

摘要："ObjectiveTo investigate the effects of combination therapy with and without batroxobin, and the frequency of batroxobin use on the prognosis of profound sudden sensorineural hearing loss.MethodsHearing recovery in the batroxobin group (231 patients) and non-batroxobin group (56 patients) was compared. The correlation between the number of times batroxobin was used and hearing recovery was analysed.ResultsThe decrease in hearing threshold and overall improvement rate in the batroxobin group with hearing loss exceeding 100 dB HL was significantly higher than that in the non-batroxobin group. There was no linear correlation between the number of times batroxobin was used and the overall improvement rate. Using batroxobin two to three times achieved a therapeutic effectiveness plateau.ConclusionBatroxobin can improve the efficacy of combination therapy for profound sudden sensorineural hearing loss exceeding 100 dB HL, and using batroxobin two to three times yields the maximum overall improvement rate."

基金机构：Hospital Cultivation Program [2018PYJJ-02]; Hospital Cultivation Program - First Affiliated Hospital of Chongqing Medical University [2020MSXM107]; Science and Health Joint Project of Chongqing

基金资助正文：We thank International Science Editing (http://www.internationalscienceediting.com) for editing this manuscript. This research was supported by the Hospital Cultivation Program funded by the First Affiliated Hospital of Chongqing Medical University (2018PYJJ-02) and the Science and Health Joint Project of Chongqing (2020MSXM107).