YAP1 affects the prognosis through the regulation of stemness in endometrial cancer

作者全名："Kong, Wei; Huang, Yuzhen; Jiang, Peng; Tu, Yuan; Li, Ning; Wang, Jinyu; Zhou, Qian; Zheng, Yunfeng; Gou, Shikai; Tian, Chenfan; Yuan, Rui"

作者地址："[Kong, Wei; Huang, Yuzhen; Jiang, Peng; Tu, Yuan; Li, Ning; Wang, Jinyu; Zhou, Qian; Zheng, Yunfeng; Gou, Shikai; Tian, Chenfan; Yuan, Rui] Chongqing Med Univ, Affiliated Hosp 1, Dept Gynecol, Chongqing, Peoples R China"

通信作者："Yuan, R (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Gynecol, Chongqing, Peoples R China."

来源：PEERJ

ESI学科分类：Multidisciplinary

WOS号：WOS:001106668600002

JCR分区：Q2

影响因子：2.3

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Endometrial cancer; Stemness; YAP1; Prognosis; Stem cell

摘要："Background. Endometrial cancer stem-like cells (ECSCs) have been proven to be responsible for recurrence, metastasis, and drug-resistance in patients with endometrial cancer. The HIPPO pathway has been shown to play an important role in the development and maintenance of stemness in a variety of tumors. While there was less research about its function in ECSCs. The aim of this study was to explore the role of YAP1, a core molecular of HIPPO pathway, in the stemness of endometrial cancer and to reveal its influence on prognosis.Methods. We collected specimens and clinical data from 774 patients with endometrial cancer to analyze the correlation between YAP1 expression and prognosis. We then examined the expression of YAP1 in ECSCs and EC cell lines (Ishikawa; HEC1-A) in vitro experiments. Changes in the stemness of cell lines were detected after YAP1 silencing by siRNA. Finally, high-throughput sequencing was used to predict the potential molecular interactions and mechanisms of YAP1's effect on stemness.Result. Down-regulation of YAP1 significantly suppresses the stemness of EC cell lines. High expression of YAP1 leads to poor prognosis in EC by regulation of stemness.Conclusion. YAP1 plays an important role in the prognosis of patients with EC by regulation of stemness."

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