Anti-Seizure Monotherapy and Early Abortion Under Real-World Conditions

作者全名："Chen, Yuanyuan; Wu, Junhong; Zhang, Hui; Chen, Hongnian; Tian, Xin; Jing, Wei; Wang, Xuefeng"

作者地址："[Chen, Yuanyuan; Wu, Junhong; Zhang, Hui; Chen, Hongnian; Tian, Xin; Jing, Wei; Wang, Xuefeng] Chongqing Med Univ, Dept Neurol, Chongqing Key Lab Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Jing, Wei] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Hosp 3,Shanxi Acad Med Sci, Taiyuan, Peoples R China"

通信作者："Tian, X (通讯作者)，Chongqing Med Univ, Dept Neurol, Chongqing Key Lab Neurol, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：NEUROLOGY INDIA

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001107453900012

JCR分区：Q4

影响因子：2.7

年份：2023

卷号：71

期号：5

开始页：928

结束页：932

文献类型：Article

关键词：Anti-seizure medication; early abortion; epilepsy; monotherapy; pregnancy

摘要："Background: Most pregnant epilepsy patients need to continue using anti-seizure medications (ASMs) to control epileptic seizures. Objective: This study aimed to evaluate the risk of early abortion in pregnant epilepsy patients exposed to anti-seizure monotherapy. Methods and Material: We prospectively followed up pregnant epilepsy patients treated with anti-seizure monotherapy in our epilepsy center between January 2010 and January 2020 under real-world conditions. Early abortion (spontaneous abortion in the first trimester of pregnancy) was the endpoint. Results: Of 211 pregnancies exposed to monotherapy, including 40% (n = 85) to lamotrigine (LTG), 28% (n = 58) to oxcarbazepine (OXC), 15% (n = 32) to sodium valproate (VPA), 9% (n = 19) to levetiracetam, and 8% (n = 17) to carbamazepine, six ended in early abortion. The overall risk of early abortion in pregnant patients exposed to ASM monotherapy was 2.8% (n = 6) [95% confidence interval (CI) = 0.013-0.073]. The risk of early abortion was 2.4% (n = 2) (95% CI = 0.003-0.082) in women treated with LTG, 3.5% (n = 2) (95% CI = 0.004-0.115) in women treated with OXC, and 6.3% (n = 2) (95% CI = 0.008-0.208) in women treated with VPA. The relative risk of early abortion in the LTG, OXC, and VPA groups did not reach statistical significance. Conclusions: Although the sample size of our study was small, these results indicate that the use of anti-seizure monotherapy in pregnant epilepsy patients may not increase the risk of early miscarriage. Larger prospective studies are needed for sufficient statistical analysis."

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