Bidirectional Relationship Between Circadian Rhythm and Frailty

作者全名："Pan, Yu; Feng, Zhu Qing; Yuan, Yan; Hu, Gui Ming; Jiang, Yi; Dong, Jiang Chuan"

作者地址："[Pan, Yu; Feng, Zhu Qing; Yuan, Yan; Hu, Gui Ming; Jiang, Yi; Dong, Jiang Chuan] Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr, Chongqing 400010, Peoples R China; [Dong, Jiang Chuan] Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr, 74 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Dong, JC (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：NATURE AND SCIENCE OF SLEEP

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001108916600001

JCR分区：Q2

影响因子：3

年份：2023

卷号：15

期号：　

开始页：949

结束页：953

文献类型：Article

关键词：circadian rhythm; frailty; metabolism; neuropathy; insulin resistance

摘要："Coupled with the ageing population, frailty, characterized by high prevalence and difficult treatment, has progressively evolved into a significant public health concern. Frail individuals can often observe serious metabolic disorders and sleep-wake cycle disruption, which may be caused by the decline in physiological reserve and increased vulnerability. Moreover, sleep-wake cycle disruptions and metabolic dysfunctions associated with circadian rhythm disorders are considered to be a central part of the disorder. Previous studies have documented a correlation between frailty and sleep-wake disruptions; nevertheless, the association between circadian rhythm disorders and frailty has not yet been definitively established. Hence, we hypothesize a bidirectional link between circadian rhythm disorders and frailty, with each condition exerting a significant influence on the progression of the other's disease trajectory."

基金机构：Chongqing Medical University [No.W0070]; Chongqing Natural Science Foundation [CSTB2022NSCQ-MSX0125]

基金资助正文："This work was supported by the 2021 Future Medical Innovation Team Support Program of Chongqing Medical University (Project No.W0070) and Chongqing Natural Science Foundation (Project No.CSTB2022NSCQ-MSX0125) . Yu Pan, Zhu Qing Feng and Yan Yuan, are co-first authors of this paper."