Mendelian randomization analysis reveals the impact of physical and occupational activities on the risk of gastroesophageal reflux disease and Barrett's esophagus

作者全名:"Wan, Li; Zuo, Hong-Zhou; Li, De-wei"

作者地址:"[Wan, Li; Li, De-wei] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing, Peoples R China; [Zuo, Hong-Zhou] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Li, De-wei] Chongqing Univ, Canc Hosp, Hepatobiliary & Pancreat Canc Ctr, Chongqing, Peoples R China"

通信作者:"Li, DW (通讯作者),Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing, Peoples R China."

来源:SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

ESI学科分类:CLINICAL MEDICINE

WOS号:WOS:001109283300001

JCR分区:Q3

影响因子:1.9

年份:2024

卷号:59

期号:3

开始页:246

结束页:253

文献类型:Article

关键词:Gastroesophageal reflux disease; Barrett's esophagus; physical activity; occupational activity; Mendelian randomization; GWAS

摘要:"BackgroundRecent studies have indicated that participating in physical activity may provide a safeguard against gastroesophageal reflux disease (GERD). Nevertheless, the precise links between physical and occupational activity and the occurrence of GERD and Barrett's esophagus (BE) are still uncertain.MethodsConducting univariate and multivariate Mendelian randomization investigations to examine the causal relationship between exposures and outcomes. Genetic variation simulation was used in randomized experiments. Data on physical and occupational activity were obtained from the UK Biobank and GWAS catalog. In the meantime, data on GERD and BE were extracted from a high quality meta-analysis.ResultsThe results of univariate Mendelian randomization analysis using multiple methods suggest a causal relationship between strenuous sports or other forms of exercise (as a protective factor) and GERD/BE. At the same time, three types of occupational related physical activities, including heavy manual or physical work, shift work and walking or standing work, are risk factors for GERD/BE and have a causal relationship with them. These results were reconfirmed through multivariate Mendelian randomization analysis, which excluding the influence of other potential confounding factors.ConclusionsThe findings indicated that strenuous sports or other forms of exercise could lower the likelihood of GERD/BE, while excessive physical strain in the workplace, prolonged periods of standing or walking, and shift work could raise the risk of GERD/BE. Acknowledging this risk and implementing suitable measures can contribute to the prevention of GERD and BE, thus mitigating the associated health burden."

基金机构:National Natural Science Foundation of China [81470898]

基金资助正文:"This work was supported by National Natural Science Foundation of China, 81470898."