Chromosome analysis of foetal tissue from 1903 spontaneous abortion patients in 5 regions of China: a retrospective multicentre study

作者全名："Zhang, Jian; Mu, Fangxiang; Guo, Zhongjie; Cai, Zhuhua; Zeng, Xianghui; Du, Lirong; Wang, Fang"

作者地址："[Zhang, Jian; Mu, Fangxiang; Zeng, Xianghui; Wang, Fang] Lanzhou Univ, Dept Cardiovasc Med, Hosp 2, Lanzhou 730030, Peoples R China; [Mu, Fangxiang] Chongqing Med Univ, Obstet Dept, Affiliated Hosp 1, Chongqing 400042, Peoples R China; [Guo, Zhongjie] Guangdong Pharmaceut Univ, Obstet Dept, Hosp Affiliated 3, Guangzhou 510410, Guangdong, Peoples R China; [Cai, Zhuhua] Ruian Peoples Hosp, Gynaecol Dept, Wenzhou 325207, Peoples R China; [Zeng, Xianghui] Qinghai Prov Peoples Hosp, Dept Reprod Med, Xining 810007, Peoples R China; [Du, Lirong] Hebei Reprod Hlth Hosp, Eugenics Clin Dept, Shijiazhuang 050090, Peoples R China"

通信作者："Wang, F (通讯作者)，Lanzhou Univ, Dept Cardiovasc Med, Hosp 2, Lanzhou 730030, Peoples R China."

来源：BMC PREGNANCY AND CHILDBIRTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001109355600002

JCR分区：Q1

影响因子：2.8

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Foetal chromosome karyotypes; Spontaneous abortion; Retrospective multicentre study

摘要："BackgroundAbnormal foetal tissue chromosome karyotypes are one of the important pathogenic factors for spontaneous abortion (SA). To investigate the age and abnormal foetal karyotypes of 1903 couples who experienced SA.MethodsA retrospective multicentre study collected age and foetal tissue karyotypes CNV-seq data of 1903 SA couples from 6 hospitals in 5 regions from January 2017 to March 2022. The distribution and correlation of abnormal foetal tissue karyotypes were evaluated by using regions and age.ResultsIn our study, 1140 couples (60.5% of the total) had abnormal foetal tissue chromosome karyotypes in all regions. We found that there were differences in the number of abnormal foetal tissue chromosome karyotypes, of which the incidence of trisomy was higher. At the same time, the populations situated in the eastern region had a more triploid (15.5%) distribution, trisomy (58.1%) in the southern region, mosaicism (14.8%) and microduplication (31.7%) in the southwestern region, microdeletion (16.7%) in the northern region. There are variances across areas, and it is more common in the north. The incidence risk of prenatal chromosomal abnormalities varied according to age group.ConclusionThe findings of this study suggest that the karyotypes of patients with abnormal foetal tissue chromosome abortion in different regions were different. Meanwhile, patients >= 35 years old had a higher risk of abnormal foetal tissue chromosome abortion."

基金机构："the Science Foundation of Lanzhou University; Lanzhou University Second Hospital; First Affiliated Hospital of Chongqing Medical University, Guangdong Pharmaceutical University Third Affiliated Hospital; Hebei Reproductive Health Hospital"

基金资助正文："We acknowledge the support received from the Lanzhou University Second Hospital. Meanwhile, we acknowledge the department leaders (Fangxiang Mu, Zhongjie Guo, Zhuhua Cai, Xianghui Zeng, and Lirong Du) of other hospitals and their hospitals (The First Affiliated Hospital of Chongqing Medical University, Guangdong Pharmaceutical University Third Affiliated Hospital, Rui'an People's Hospital, Qinghai Provincial People's Hospital, and Hebei Reproductive Health Hospital) that have provided data. In particularly, useful suggestions and supports given by Professor Fang Wang."