Exploring the causal relationship between periodontitis and gut microbiome: Unveiling the oral-gut and gut-oral axes through bidirectional Mendelian randomization

作者全名："Chen, Hang; Peng, Limin; Wang, Zhenxiang; He, Yujuan; Zhang, Xiaonan"

作者地址："[Chen, Hang; Peng, Limin; Wang, Zhenxiang; Zhang, Xiaonan] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China; [Chen, Hang; Peng, Limin; Wang, Zhenxiang; Zhang, Xiaonan] Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China; [Chen, Hang; Peng, Limin; Wang, Zhenxiang; Zhang, Xiaonan] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [He, Yujuan] Chongqing Med Univ, Dept Lab Med, Key Lab Diagnost Med, Minist Educ, Chongqing, Peoples R China; [Zhang, Xiaonan] Chongqing Med Univ, Coll Stomatol, 426 Songshibei Rd, Chongqing, Peoples R China"

通信作者："Zhang, XA (通讯作者)，Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China.; Zhang, XA (通讯作者)，Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China.; Zhang, XA (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China.; Zhang, XA (通讯作者)，Chongqing Med Univ, Coll Stomatol, 426 Songshibei Rd, Chongqing, Peoples R China."

来源：JOURNAL OF CLINICAL PERIODONTOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001109476700001

JCR分区：Q1

影响因子：5.8

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：gut microbiome; gut-oral axis; Mendelian randomization; oral-gut axis; periodontitis

摘要："AimThis Mendelian randomization (MR) study was performed to explore the potential bidirectional causal relationship between the gut microbiome (GM) and periodontitis.Materials and MethodsWe used genetic instruments from the genome-wide association study of European descent for periodontitis from the GeneLifestyle Interactions in Dental Endpoints (GLIDE) consortium (17,353 cases and 28,210 controls) and the FinnGen consortium (4434 cases and 259,234 controls) to investigate the causal relationship with GM (the MiBioGen consortium, 18,340 samples), and vice versa. Several MR techniques, which include inverse variance weighting (IVW), MR-Egger, weighted median, simple mode and weighted mode approaches, were employed to investigate the causal relationship between the exposures and the outcomes. Cochran's Q-test was performed to detect heterogeneity. The MR-Egger regression intercept and MR pleiotropy residual sum and outlier test (MR-PRESSO) were conducted to test potential horizontal pleiotropy. Leave-one-out sensitivity analyses were used to assess the stabilities of single nucleotide polymorphisms (SNPs). Finally, the IVW results from the two databases were analysed using meta-analysis.ResultsWe confirmed three potential causal relationships between GM taxa and periodontitis at the genus level. Among them, the genera Alistipes and Holdemanella were genetically associated with an increased risk of periodontitis. In reverse, periodontitis may lead to a decreased abundance of the genus Ruminococcaceae UCG014.ConclusionsThe demonstration of a causal link between GM and periodontitis provides compelling evidence, highlighting the interconnectivity and interdependence of the gut-oral and oral-gut axes."

基金机构："Natural Science Foundation Project of Chongqing, China [CSTB2022NSCQ-MSX0084]; National Natural Science Foundation of China [81700982]; Chongqing Medical Reserve Talent Studio [ZQNYXGDRCGZS2019004]"

基金资助正文："This work was financially supported by the Natural Science Foundation Project of Chongqing, China (CSTB2022NSCQ-MSX0084), the National Natural Science Foundation of China (81700982) and the Chongqing Medical Reserve Talent Studio for Young People(ZQNYXGDRCGZS2019004)."