Association between serum polyunsaturated fatty acids and bone mineral density in US adults: NHANES 2011-2014

作者全名："Liang, Hao; Xiong, Chuang; Luo, Yuangang; Zhang, Jun; Huang, Yanran; Zhao, Runhan; Zhou, Nian; Zhao, Zenghui; Luo, Xiaoji"

作者地址："[Liang, Hao; Zhang, Jun; Huang, Yanran; Zhao, Runhan; Zhou, Nian; Zhao, Zenghui; Luo, Xiaoji] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped Surg, Chongqing, Peoples R China; [Liang, Hao; Zhang, Jun; Huang, Yanran; Zhao, Runhan; Zhou, Nian; Zhao, Zenghui; Luo, Xiaoji] Orthoped Lab Chongqing Med Univ, Chongqing, Peoples R China; [Xiong, Chuang] Chongqing Univ Canc Hosp, Dept Bone & Soft Tissue Oncol, Chongqing, Peoples R China; [Luo, Yuangang] Qianjiang Cent Hosp Chongqing, Dept Orthoped, Chongqing, Qianjiang, Peoples R China"

通信作者："Luo, XJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped Surg, Chongqing, Peoples R China.; Luo, XJ (通讯作者)，Orthoped Lab Chongqing Med Univ, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001111538600001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：polyunsaturated fatty acids; docosapentaenoic acid (DPA); eicosadienoic acid (EDA); bone mineral density; NHANES

摘要："ObjectiveThe purpose of this study was to investigate the association between serum polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD).MethodsWe performed a cross-sectional study based on data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. The weighted multiple linear regression model was utilized to determine the association between serum PUFAs and BMD. Further smoothed curve fitting and threshold effect analysis were conducted. Finally, we performed a subgroup analysis.ResultsIn total, 1979 participants aged 20-59 years were enrolled. After adjusting for all covariates, we found that serum docosapentaenoic acid (DPA) was positively associated with head BMD (beta = 0.0015, 95% Cl: 0.0004, 0.0026, P = 0.008296) and lumbar spine BMD (beta = 0.0005, 95% Cl: 0.0000, 0.0010, P = 0.036093), and serum eicosadienoic acid (EDA) was negatively associated with thoracic spine BMD (beta = -0.0008, 95% Cl: -0.0016, -0.0000, P = 0.045355). Smoothed curve fitting revealed a nonlinear positive association between serum DPA and lumbar spine BMD. Threshold effect analysis indicated that the threshold of serum DPA was 81.4 mu mol/L. Subgroup analysis revealed a positive correlation between serum DPA and head BMD in the subgroup aged 50-59 years (beta = 0.0025, 95% Cl: 0.0002, 0.0049, P = 0.035249) and females (beta = 0.0026, 95% Cl: 0.0008, 0.0044, P = 0.005005). There was a positive relationship between serum DPA and lumbar spine BMD in females (beta = 0.0008, 95% Cl: 0.0001, 0.0015, P = 0.017900) and a negative association between serum EDA and thoracic spine BMD in the subgroup aged 30-39 years (beta = -0.0016, 95% Cl: -0.0031, -0.0001, P = 0.041331), males (beta = -0.0012, 95% Cl: -0.0023, -0.0001, P = 0.039364) and other races (beta = -0.0021, 95% Cl: -0.0037, -0.0006, P = 0.008059).ConclusionThis study demonstrated a linear positive relationship between serum DPA and head BMD, a nonlinear positive association between serum DPA and lumbar spine BMD, and a linear negative correlation between serum EDA and thoracic spine BMD in US adults."

基金机构：Program for Youth Innovation in Future Medicine of Chongqing Medical University [W0086]; Chongqing Technical Innovation and Application Development Special Project [CSTB2021TIAD-KPX0060]; Chongqing Talent Plan for Innovative Leading talents [CQYC20210303373]

基金资助正文："The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Program for Youth Innovation in Future Medicine of Chongqing Medical University (Nos. W0086), Chongqing Technical Innovation and Application Development Special Project (CSTB2021TIAD-KPX0060), and the Chongqing Talent Plan for Innovative Leading talents (CQYC20210303373)."