"CD8<SUP>+</SUP> T cells in fetal membranes display a unique phenotype, and their activation is involved in the pathophysiology of spontaneous preterm birth"

作者全名："Jiang, Yinan; Lai, Xintong; Liu, Yuxu; Yang, Cheng; Liu, Zhicui; Liu, Xiaorui; Yu, Tiantian; Chen, Cailian; Khanniche, Asma; Fan, Jianxia; Lin, Yi; Zeng, Weihong"

作者地址："[Jiang, Yinan; Lai, Xintong; Liu, Yuxu; Liu, Xiaorui; Yu, Tiantian; Fan, Jianxia; Zeng, Weihong] Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Shanghai Key Lab Embryo Original Dis, Sch Med, Shanghai, Peoples R China; [Yang, Cheng] Chongqing Med Univ, Dept Infect Dis, Affiliated Hosp1, Chongqing, Peoples R China; [Liu, Zhicui] Tongji Univ, Shanghai Peoples Hosp 10, Dept Dermatol, Sch Med, Shanghai, Peoples R China; [Chen, Cailian] Shanghai Jiao Tong Univ, Dept Automat, Key Lab Syst Control & Informat Proc, Minist Educ China, Shanghai, Peoples R China; [Khanniche, Asma] Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China; [Lin, Yi] Shanghai Jiao Tong Univ, Reprod Med Ctr, Sch Med, Peoples Hosp 6, Shanghai, Peoples R China; [Zeng, Weihong] Shanghai Jiao Tong Univ, Reprod Med Ctr, Sch Med, Peoples Hosp 6, 910 Hengshan Rd,600 YiShan Rd, Shanghai 200030, Peoples R China; [Lin, Yi] Shanghai Jiao Tong Univ, Peoples Hosp 6, Reprod Med Ctr, Sch Med, 600 Yi Shan Rd, Shanghai 200233, Peoples R China"

通信作者："Zeng, WH (通讯作者)，Shanghai Jiao Tong Univ, Reprod Med Ctr, Sch Med, Peoples Hosp 6, 910 Hengshan Rd,600 YiShan Rd, Shanghai 200030, Peoples R China.; Lin, Y (通讯作者)，Shanghai Jiao Tong Univ, Peoples Hosp 6, Reprod Med Ctr, Sch Med, 600 Yi Shan Rd, Shanghai 200233, Peoples R China."

来源：JOURNAL OF PATHOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001111619200001

JCR分区：Q1

影响因子：5.6

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：spontaneous preterm birth; CD8(+) T cells; central memory subset; fetal membranes; placentas; umbilical cord blood; T-cell activation

摘要："Preterm labor/birth is the leading cause of perinatal mortality and morbidity worldwide. Previous studies demonstrated that T cells were crucial for maintaining maternal-fetal immune tolerance during the first trimester of pregnancy; however, their phenotypes and functions in labor and delivery remain largely unknown. We recruited three cohorts of women at delivery for T-cell immunophenotyping in the placentas, fetal membranes, umbilical cord blood, and maternal peripheral blood. Our data showed a differential enrichment of T cells during the third trimester of human pregnancy, with CD4(+) T cells being more observable within the umbilical cord blood, whereas CD8(+) T cells became relatively more abundant in fetal membranes. CD4(+) and CD8(+) T cells derived from fetal membranes were dominated by effector memory T cells and exhibited extensive expression of activation markers but decreased expression of homing receptor. In comparison with term births, fetal membrane CD8(+) T cells, especially the central memory subset, were significantly increased in frequency and showed more profound activation in spontaneous preterm birth patients. Finally, using an allogeneic mouse model, we found that T-cell-activation-induced preterm birth could be alleviated by the depletion of CD8(+) T but not CD4(+) T cells in vivo. Collectively, we showed that CD8(+) T cells in fetal membranes displayed a unique phenotype, and their activation was involved in the pathophysiology of spontaneous preterm birth, which provides novel insights into the immune mechanisms of preterm birth and potential targets for the prevention of this syndrome. (c) 2023 The Pathological Society of Great Britain and Ireland."

基金机构："National Key Research and Development Program of China; National Natural Science Foundation of China [81974243, 32000664]; Natural Science Foundation of Shanghai [22ZR1467700]; Shanghai Pujiang Program [22PJD083, 22PJD057]; Innovative Research Team of High-level Local Universities in Shanghai (SHSMU-ZLCX20210202), Funds for Outstanding Newcomers, Shanghai Sixth People's Hospital [X-3664]; Shanghai Jiao Tong University [20210201]; Chongqing Innovation Plan for Overseas Returnees [cx2020037]; Chongqing Yuzhong Science and Technology Commission [20200119]; [2018YFC1004602]"

基金资助正文："This work was supported by the National Key Research and Development Program of China (grant 2018YFC1004602), National Natural Science Foundation of China (81974243, 32000664), Natural Science Foundation of Shanghai (22ZR1467700), Shanghai Pujiang Program (22PJD083 and 22PJD057), Innovative Research Team of High-level Local Universities in Shanghai (SHSMU-ZLCX20210202), Funds for Outstanding Newcomers, Shanghai Sixth People's Hospital (X-3664), Shanghai Jiao Tong University Trans-Med Awards Research (20210201), Chongqing Innovation Plan for Overseas Returnees (cx2020037), and Chongqing Yuzhong Science and Technology Commission (20200119)."