Cortical and subcortical structural differences in psychostimulant-free ADHD youth with and without a family history of bipolar I disorder: a cross-sectional morphometric comparison

作者全名："Zhu, Ziyu; Lei, Du; Qin, Kun; Tallman, Maxwell; Patino, L. Rodrigo; Fleck, David; Gong, Qiyong; Sweeney, John; Delbello, Melissa; Mcnamara, Robert"

作者地址："[Zhu, Ziyu; Qin, Kun; Gong, Qiyong; Sweeney, John] Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Dept Radiol, Chengdu 610041, Peoples R China; [Zhu, Ziyu; Qin, Kun; Tallman, Maxwell; Patino, L. Rodrigo; Fleck, David; Sweeney, John; Delbello, Melissa; Mcnamara, Robert] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45219 USA; [Lei, Du] Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China; [Qin, Kun] Chinese Acad Med Sci, Res Unit Psychoradiol, Chengdu, Sichuan, Peoples R China; [Qin, Kun] Hubei Univ Med, Taihe Hosp, Dept Radiol, Shiyan 442012, Peoples R China; [Gong, Qiyong] Sichuan Univ, Dept Radiol, West China Xiamen Hosp, Xiamen 361021, Fujian, Peoples R China"

通信作者："Gong, QY (通讯作者)，Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Dept Radiol, Chengdu 610041, Peoples R China.; Lei, D (通讯作者)，Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China.; Gong, QY (通讯作者)，Sichuan Univ, Dept Radiol, West China Xiamen Hosp, Xiamen 361021, Fujian, Peoples R China."

来源：TRANSLATIONAL PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001111620300002

JCR分区：Q1

影响因子：5.8

年份：2023

卷号：13

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Although attention-deficit/hyperactivity disorder (ADHD) and a family history of bipolar I disorder (BD) are associated with increased risk for developing BD, their neuroanatomical substrates remain poorly understood. This study compared cortical and subcortical gray matter morphology in psychostimulant-free ADHD youth with and without a first-degree relative with BD and typically developing healthy controls. ADHD youth (ages 10-18 years) with ('high-risk', HR) or without ('low-risk', LR) a first-degree relative with BD and healthy comparison youth (HC) were enrolled. High-resolution 3D T1-weighted images were acquired using a Philips 3.0 T MR scanner. The FreeSurfer image analysis suite was used to measure cortical thickness, surface area, and subcortical volumes. A general linear model evaluated group differences in MRI features with age and sex as covariates, and exploratory correlational analyses evaluated associations with symptom ratings. A total of n = 142 youth (mean age: 14.16 +/- 2.54 years, 35.9% female) were included in the analysis (HC, n = 48; LR, n = 49; HR, n = 45). The HR group exhibited a more severe symptom profile, including higher mania and dysregulation scores, compared to the LR group. For subcortical volumes, the HR group exhibited smaller bilateral thalamic, hippocampal, and left caudate nucleus volumes compared to both LR and HC, and smaller right caudate nucleus compared with LR. No differences were found between LR and HC groups. For cortical surface area, the HR group exhibited lower parietal and temporal surface area compared with HC and LR, and lower orbitofrontal and superior frontal surface area compared to LR. The HR group exhibited lower left anterior cingulate surface area compared with HC. LR participants exhibited greater right pars opercularis surface area compared with the HC. Some cortical alterations correlated with symptom severity ratings. These findings suggest that ADHD in youth with a BD family history is associated with a more a severe symptom profile and a neuroanatomical phenotype that distinguishes it from ADHD without a BD family history."

基金机构："National Natural Science Foundation of China (National Science Foundation of China) [097818]; R01 NIMH [81820108018, 82027808]; National Natural Science Foundation of China; Chongqing Talents Exceptional Young Talents Project"

基金资助正文："We thank all participants for their time and willingness to take part in this study. This study was supported in part by R01 NIMH grant 097818 to R.K.M and M.P.D (Co-PIs) and the National Natural Science Foundation of China (Q.G., Grant No. 81820108018, 82027808). Du Lei was supported by the Chongqing Talents Exceptional Young Talents Project. The funders had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication."