The Landscape of Biomimetic Nanovesicles in Brain Diseases
作者全名："You, Qing; Liang, Fuming; Wu, Gege; Cao, Fangfang; Liu, Jingyi; He, Zhaohui; Wang, Chen; Zhu, Ling; Chen, Xiaoyuan; Yang, Yanlian"
作者地址："[You, Qing; Liang, Fuming; Liu, Jingyi; Wang, Chen; Zhu, Ling; Yang, Yanlian] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Standardizat & Measurement Nanotechnol, Beijing 100190, Peoples R China; [You, Qing; Wu, Gege; Cao, Fangfang; Chen, Xiaoyuan] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Diagnost Radiol, Singapore 119074, Singapore; [You, Qing; Wu, Gege; Cao, Fangfang; Chen, Xiaoyuan] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg Chem & Biomol Engn, Singapore 119074, Singapore; [You, Qing; Wu, Gege; Cao, Fangfang; Chen, Xiaoyuan] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biomed Engn, Singapore 119074, Singapore; [You, Qing; Wu, Gege; Cao, Fangfang; Chen, Xiaoyuan] Natl Univ Singapore, Coll Design & Engn, Singapore 119074, Singapore; [You, Qing; Wu, Gege; Cao, Fangfang; Chen, Xiaoyuan] Natl Univ Singapore, Yong Loo Lin Sch Med, Nanomed Translat Res Program, Singapore 117597, Singapore; [You, Qing; Wu, Gege; Cao, Fangfang; Chen, Xiaoyuan] Natl Univ Singapore, Clin Imaging Res Ctr, Ctr Translat Med, Yong Loo Lin Sch Med, Singapore 117599, Singapore; [You, Qing; Wu, Gege; Cao, Fangfang; Chen, Xiaoyuan] ASTAR, Inst Mol & Cell Biol, 61 Biopolis Dr, Singapore 138673, Singapore; [Liang, Fuming; He, Zhaohui] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, 1 Friendship Rd, Chongqing 400016, Peoples R China; [Liu, Jingyi; Wang, Chen; Zhu, Ling; Yang, Yanlian] Univ Chinese Acad Sci, Sch Nanosci & Engn, Beijing 100049, Peoples R China"
通信作者："Zhu, L; Yang, YL (通讯作者)，Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Standardizat & Measurement Nanotechnol, Beijing 100190, Peoples R China.; Chen, XY (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Diagnost Radiol, Singapore 119074, Singapore.; Chen, XY (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg Chem & Biomol Engn, Singapore 119074, Singapore.; Chen, XY (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biomed Engn, Singapore 119074, Singapore.; Chen, XY (通讯作者)，Natl Univ Singapore, Coll Design & Engn, Singapore 119074, Singapore.; Chen, XY (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Nanomed Translat Res Program, Singapore 117597, Singapore.; Chen, XY (通讯作者)，Natl Univ Singapore, Clin Imaging Res Ctr, Ctr Translat Med, Yong Loo Lin Sch Med, Singapore 117599, Singapore.; Chen, XY (通讯作者)，ASTAR, Inst Mol & Cell Biol, 61 Biopolis Dr, Singapore 138673, Singapore.; Zhu, L; Yang, YL (通讯作者)，Univ Chinese Acad Sci, Sch Nanosci & Engn, Beijing 100049, Peoples R China."
来源：ADVANCED MATERIALS
ESI学科分类：MATERIALS SCIENCE
WOS号：WOS:001112443300001
JCR分区：Q1
影响因子：27.4
年份：2023
卷号：
期号：
开始页：
结束页：
文献类型：Review; Early Access
关键词：biomimetic nanovesicles; brain disease; drug delivery; in vitro diagnosis; nanotechnology
摘要："Brain diseases, such as brain tumors, neurodegenerative diseases, cerebrovascular diseases, and brain injuries, are caused by various pathophysiological changes, which pose a serious health threat. Brain disorders are often difficult to treat due to the presence of the blood-brain barrier (BBB). Biomimetic nanovesicles (BNVs), including endogenous extracellular vesicles (EVs) derived from various cells and artificial nanovesicles, possess the ability to penetrate the BBB and thus can be utilized for drug delivery to the brain. BNVs, especially endogenous EVs, are widely distributed in body fluids and usually carry various disease-related signal molecules such as proteins, RNA, and DNA, and may also be analyzed to understand the etiology and pathogenesis of brain diseases. This review covers the exhaustive classification and characterization of BNVs and pathophysiological roles involved in various brain diseases, and emphatically focuses on nanotechnology-integrated BNVs for brain disease theranostics, including various diagnosis strategies and precise therapeutic regulations (e.g., immunity regulation, disordered protein clearance, anti-neuroinflammation, neuroregeneration, angiogenesis, and the gut-brain axis regulation). The remaining challenges and future perspectives regarding the nanotechnology-integrated BNVs for the diagnosis and treatment of brain diseases are also discussed and outlined. This review provides the recent progress on nanotechnology-integrated biomimetic nanovesicles (BNVs) for brain diseases from various aspects of classification and characterization of BNVs and involved pathophysiological roles, with focus on nanotechnology-based biomedical applications, including in vitro diagnosis and precise therapeutic regulations, and also outlines the remaining challenges and future perspectives.image"
基金机构："National University of Singapore; National Medical Research Council [OFYIRG23jan-0005, CG21APR1005]; Ministry of Education - Singapore [MOE-000387-00]; National Research Foundation; Strategic Priority Research Program of Chinese Academy of Sciences [XDB36000000]; National Key Research and Development Program of China [2021YFA1201504]; National Natural Science Foundation of China [31971295]; [NUHSRO/2020/133/Startup/08]; [NUHSRO/2023/008/NUSMed/TCE/LOA]; [NUHSRO/2021/034/TRP/09/Nanomedicine]"
基金资助正文："Q.Y. and F.L. contributed equally to this work. This work was financially supported by the National University of Singapore (Grant Nos. NUHSRO/2020/133/Startup/08, NUHSRO/2023/008/NUSMed/TCE/LOA, NUHSRO/2021/034/TRP/09/Nanomedicine), the National Medical Research Council (Grant Nos. OFYIRG23jan-0005, CG21APR1005), the Ministry of Education - Singapore (Grant No. MOE-000387-00), the National Research Foundation (Grant No. NRF-000352-00), the Strategic Priority Research Program of Chinese Academy of Sciences (Grant No. XDB36000000), the National Key Research and Development Program of China (Grant No. 2021YFA1201504), the National Natural Science Foundation of China (Grant No. 31971295)."
