Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

作者全名："Ding, Yi; Xu, Xiaoli; Xin, Zhuojun; Cao, Qiuyu; Huang, Jiaojiao; Wu, Xianglin; Huo, Yanan; Wan, Qin; Qin, Yingfen; Hu, Ruying; Shi, Lixin; Su, Qing; Yu, Xuefeng; Yan, Li; Qin, Guijun; Tang, Xulei; Chen, Gang; Xu, Min; Wang, Tiange; Zhao, Zhiyun; Gao, Zhengnan; Wang, Guixia; Shen, Feixia; Luo, Zuojie; Chen, Li; Li, Qiang; Ye, Zhen; Zhang, Yinfei; Liu, Chao; Wang, Youmin; Yang, Tao; Deng, Huacong; Chen, Lulu; Zeng, Tianshu; Zhao, Jiajun; Mu, Yiming; Wu, Shengli; Chen, Yuhong; Lu, Jieli; Wang, Weiqing; Ning, Guang; Xu, Yu; Bi, Yufang; Li, Mian"

作者地址："[Ding, Yi; Xu, Xiaoli; Xin, Zhuojun; Cao, Qiuyu; Huang, Jiaojiao; Wu, Xianglin; Xu, Min; Wang, Tiange; Zhao, Zhiyun; Chen, Yuhong; Lu, Jieli; Wang, Weiqing; Ning, Guang; Xu, Yu; Bi, Yufang; Li, Mian] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai 200025, Peoples R China; [Ding, Yi; Xu, Xiaoli; Xin, Zhuojun; Cao, Qiuyu; Huang, Jiaojiao; Wu, Xianglin; Xu, Min; Wang, Tiange; Zhao, Zhiyun; Chen, Yuhong; Lu, Jieli; Wang, Weiqing; Ning, Guang; Xu, Yu; Bi, Yufang; Li, Mian] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Natl Clin Res Ctr Metab Dis, Key Lab Endocrine & Metab Dis,Natl Hlth Commiss Ch, Shanghai 200025, Peoples R China; [Huo, Yanan] Nanchang Univ, Jiangxi Prov Peoples Hosp, Nanchang 330000, Peoples R China; [Wan, Qin] Southwest Med Univ, Dept Endocrinol, Affiliated Hosp, Luzhou 646000, Peoples R China; [Qin, Yingfen; Luo, Zuojie] Guangxi Med Univ, Dept Endocrinol, Affiliated Hosp 1, Nanning 530000, Peoples R China; [Hu, Ruying; Ye, Zhen] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou 310000, Peoples R China; [Shi, Lixin] Guizhou Med Univ, Dept Endocrinol, Affiliated Hosp, Guiyang 550000, Peoples R China; [Su, Qing] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Shanghai 200000, Peoples R China; [Yu, Xuefeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430000, Peoples R China; [Yan, Li] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510000, Peoples R China; [Qin, Guijun] Zhengzhou Univ, Dept Endocrinol, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China; [Tang, Xulei] Lanzhou Univ, Dept Endocrinol, Hosp 1, Lanzhou 730000, Peoples R China; [Chen, Gang] Fujian Med Univ, Fujian Prov Hosp, Fuzhou 350000, Peoples R China; [Gao, Zhengnan] Dalian Med Univ, Dalian Municipal Cent Hosp, Dalian 116000, Peoples R China; [Wang, Guixia] First Hosp Jilin Univ, Dept Endocrinol, Changchun 130000, Peoples R China; [Shen, Feixia] Wenzhou Med Univ, Dept Endocrinol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China; [Chen, Li] Shandong Univ, Qilu Hosp, Jinan 250000, Peoples R China; [Li, Qiang] Harbin Med Univ, Dept Endocrinol, Affiliated Hosp 2, Harbin 150000, Peoples R China; [Zhang, Yinfei] Cent Hosp Shanghai Jiading Dist, Dept Emergency, Shanghai 200000, Peoples R China; [Liu, Chao] Jiangsu Prov Hosp Integrat Chinese & Western Med, Dept Endocrinol, Nanjing 210028, Peoples R China; [Wang, Youmin] Anhui Med Univ, Dept Endocrinol, Affiliated Hosp 1, Hefei 230000, Peoples R China; [Yang, Tao] Nanjing Med Univ, Dept Endocrinol, Affiliated Hosp 1, Nanjing 210000, Peoples R China; [Deng, Huacong] First Affiliated Hosp Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 1, Chongqing 410000, Peoples R China; [Chen, Lulu; Zeng, Tianshu] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan 430000, Peoples R China; [Zhao, Jiajun] Shandong Univ, Shandong Prov Hosp, Jinan 250000, Peoples R China; [Mu, Yiming] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100000, Peoples R China; [Wu, Shengli] Karamay Municipal Peoples Hosp, Dept Endocrinol, Karamay 834000, Peoples R China"

通信作者："Xu, Y; Bi, YF; Li, M (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai 200025, Peoples R China.; Xu, Y; Bi, YF; Li, M (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Natl Clin Res Ctr Metab Dis, Key Lab Endocrine & Metab Dis,Natl Hlth Commiss Ch, Shanghai 200025, Peoples R China."

来源：FRONTIERS OF MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001113012000001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：sleep; physical activity; chronic kidney disease; isotemporal substitution; behavioral pattern

摘要："Studies have found a U-shaped relationship between sleep duration and chronic kidney disease (CKD) risk, but limited research evaluated the association of reallocating excessive sleep to other behavior with CKD. We included 104 538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal Study, with self-reported time of daily-life behavior. Using isotemporal substitution models, we found that substituting 1 h of sleeping with sitting, walking, or moderate-to-vigorous physical activity was associated with a lower CKD prevalence. Leisure-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working population. In stratified analysis, a lower CKD prevalence related to substitution toward physical activity was found in long sleepers. More pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes, and they benefited from other behavior substitutions toward a more active way. The U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys, in which the pernicious link with oversleep could be reversed by time reallocation to physical activity. The divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition."

基金机构："National Natural Science Foundation of China [82088102, 91857205, 82022011, 81970728, 81930021]; Shanghai Rising-Star Program [21QA1408100]; Shanghai Outstanding Academic Leaders Plan [20XD1422800]; National Top Young Scholar Program; Innovative Research Team of High-Level Local Universities in Shanghai; Shanghai Clinical Research Center for Metabolic Diseases [19MC1910100]; Shanghai Shen Kang Hospital Development Center [SHDC2020CR1001A, SHDC2020CR3064B]"

基金资助正文："The authors thank all the staff and study participants for their important contributions. This work was supported by the grants from the National Natural Science Foundation of China (Nos. 82088102, 91857205, 82022011, 81970728, and 81930021), the Shanghai Rising-Star Program (No. 21QA1408100), Shanghai Outstanding Academic Leaders Plan (No. 20XD1422800), the National Top Young Scholar Program (Yu Xu), the Innovative Research Team of High-Level Local Universities in Shanghai, the Shanghai Clinical Research Center for Metabolic Diseases (No. 19MC1910100) and the Shanghai Shen Kang Hospital Development Center (Nos. SHDC2020CR1001A and SHDC2020CR3064B)."