Clinical and electroencephalographic characteristics of 34 infant with onset of epileptic spasms before three months of age

作者全名："Chen, Min; Yan, Lisi; Deng, Yu; Chen, Jin; Xie, Lingling; Hu, Yue; Hong, Siqi; Jiang, Li"

作者地址："Chongqing Med Univ, Childrens Hosp, Dept Neurol, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; Minist Educ, Key Lab Child Dev & Disorders, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; Natl Clin Res Ctr Child Hlth & Disorders Chongqin, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; China Int Sci & Technol Cooperat Base Child Dev &, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; Chongqing Key Lab Pediat, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China"

通信作者："Chen, J (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Neurol, Minist Educ,Key Lab Child Dev & Disorders, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：EPILEPSY & BEHAVIOR

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001113596600001

JCR分区：Q2

影响因子：2.3

年份：2023

卷号：149

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Epileptic spasms; Infantile epileptic spasms syndrome; Electroencephalography; Etiology; Infant

摘要："Epileptic spasms (ES) occur mostly between age 3 months and 24 months. ES beginning before 3 months of age were called early-onset ES in previous studies. The aim of this study was to identify clinical and electroencephalographic characteristics of patients with ES onset before 3 months of age. In total, 34 ES patients were retrospectively identified at Children's Hospital of Chongqing Medical University from January 1, 2020 to October 1, 2022. Our patients had diverse etiologies, including genetic (32.3 %), genetic-structural (11.8 %), structural-acquired (11.8 %), structural-congenital (8.8 %), and metabolic (5.9 %), with 29.4 % of patients having unknown etiology. Some patients experienced ES in clusters (either symmetrical or flexional) that occurred most often during awakening after sleep, and a minority of ES were characterized as isolated or asymmetrical, occurred during sleep, and could also manifest as relatively subtle. Approximately 35.3 % of patients also experienced other seizure types concurrently, including 10 focal seizures and 2 generalized seizures, and only half of the focal seizures had structural causes. The other seizure types occurred alone or sequentially with ES. Interictal electroencephalography revealed hypsarrhythmia or its variants, multifocal discharge, or burst suppression. 18 patients had no seizures lasting for more than 2 months, however, at the last follow-up visit, 5 of them had relapsed. All patients had different degrees of psychomotor retardation."

基金机构：National Natural Science Foundation of China [81501056]

基金资助正文：Funding statement This work was supported by the National Natural Science Foundation of China (NSFC Grant 81501056) .