A Convergent fabrication of silk fibroin nanoparticles on quercetin loaded metal-organic frameworks for promising nanocarrier of myocardial infraction

作者全名："Hao, Junjun; Lv, Ankang; Li, Xingsheng; Li, Yongyong"

作者地址："[Hao, Junjun] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Cardiovasc Surg, Xian 710061, Peoples R China; [Lv, Ankang; Li, Xingsheng; Li, Yongyong] Chongqing Med Univ, Affiliated Hosp 2, Dept Gerontol, Chongqing 400010, Peoples R China; [Li, Yongyong] Chongqing Med Univ, Affiliated Hosp 2, Dept Gerontol, 76 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Li, YY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Gerontol, 76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001114194300001

JCR分区：Q1

影响因子：3.4

年份：2023

卷号：9

期号：10

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Drug delivery; Myocardial infraction; pH-responsive; Zeolitic imidazolate framework-8 (ZIF-8); Silk fibroin

摘要："The biomacromolecule silk fibroin (SF) may be constructed to promote biomimetic nucleation and nanostructures of inorganic nanomaterials, offering it a promising candidate for use in various biomimetic applications. We combined SF-NPs and ZIF-8-NPs to fabricate new drug vehicles that effectively release the drug. SF nanoparticles (SF-NPs) were assembled into quercetin (QCT), a myocardial drug added to fabricate QSF-NPs. By acting as a template for the ZIF-8 nucleation onto the surface, the QSF-NPs fabricated core-shell-structured nanocomposites (named QSF@Z-NCs) with ZIF-8 as the core-shell and the QSF-NPs. The biocompatibility analysis using the MTT assay revealed that the developed QCT, SF-NPs, and QSF@Z-NCs are not harmful to cardiac myoblast (H9C2) cells. The in vivo model demonstrated that H9C2 cells encouraged cardiomyocyte fibre regeneration in myocardial infarction rats. We fabricated a brand-new technique using H9C2 cells and QSF@Z-NCs that might encourage the healing processes in myocardial ischemia cells. This study's results demonstrate that it successfully treats myocardial injury."

基金机构：Nan ' an District of Chongqing Science and Health Joint Medical Research Project [2021-07]

基金资助正文：<BOLD>Funding</BOLD> This work was supported by the Nan ' an District of Chongqing Science and Health Joint Medical Research Project (Project No.: 2021-07) .