Asiatic acid affects the growth of human osteosarcoma cells by regulating PI3K/AKT and NF-κB dual signal pathways

作者全名："Huang, Yanran; Xie, Zhou; Jiwa, Habu; Zhang, Jun; Wang, Yuping; Xu, Jingtao; Luo, Xiaoji"

作者地址："[Huang, Yanran; Xie, Zhou; Jiwa, Habu; Zhang, Jun; Wang, Yuping; Xu, Jingtao; Luo, Xiaoji] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China"

通信作者："Luo, XJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China."

来源：JOURNAL OF FUNCTIONAL FOODS

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001114276200001

JCR分区：Q2

影响因子：3.8

年份：2023

卷号：111

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Asiatic acid; Osteosarcoma; PI3K/AKT; NF-kappa B; Antitumor

摘要："Osteosarcoma(OS) is a common primary malignant bone tumor, which mostly occurs in children and adolescents. Currently, chemotherapy drugs for the clinical treatment of OS have high side effects and patients are prone to chemotherapy resistance, which reduces the therapeutic effect. Therefore, the development of new therapeutic drugs is very important to reduce the toxicity and adverse reactions of drugs and improve the survival rate of patients. At present, the antitumor activity of traditional Chinese medicine monomers has received extensive attention because of its safety and efficacy. Asiatic acid (AA) is a naturally pentacyclic triterpenoids extracted from Centella asiatica. The aim of this study was to evaluate the effect and mechanism of AA on OS cells in vitro and in vivo. In vitro results showed that AA inhibited the proliferation, migration and invasion of OS cells and was able to induce apoptosis and cycle arrest. In vivo results showed that AA inhibited the growth of OS and the size of lung metastasis in nude mice. Network pharmacology, molecular docking and in vitro experiments prove that AA may play a role in the treatment of OS by inhibiting PI3K/AKT and NF-kappa B signaling pathways. Our study shows that AA can act on multiple targets of OS and regulate multiple pathways to intervene in the occurrence and development of OS, which may provide reference for the clinical application and development of AA."

基金机构："National Natural Science Founda- tion of China [81873998]; Doctoral student innovation project of the First Affiliated Hospital of Chongqing Medical University [CYYY- BSYJSCXXM-2002219, CYYY-BSYJSCXXM-2002215]"

基金资助正文："This study was supported by the National Natural Science Founda- tion of China (NO.81873998) , Doctoral student innovation project of the First Affiliated Hospital of Chongqing Medical University (CYYY- BSYJSCXXM-2002219, CYYY-BSYJSCXXM-2002215) ."