Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality

作者全名："Xie, Xulin; Zhai, Jiao; Zhou, Xiaoyu; Guo, Zhengjun; Lo, Pui-Chi; Zhu, Guangyu; Chan, Kannie W. Y.; Yang, Mengsu"

作者地址："[Xie, Xulin; Zhai, Jiao; Zhou, Xiaoyu; Lo, Pui-Chi; Yang, Mengsu] City Univ Hong Kong Shenzhen, Futian Res Inst, Dept Precis Diagnost & Therapeut Technol, Shenzhen 518057, Peoples R China; [Xie, Xulin; Zhai, Jiao; Zhou, Xiaoyu; Guo, Zhengjun; Lo, Pui-Chi; Yang, Mengsu] City Univ Hong Kong, Dept Biomed Sci, 83 Tat Chee Ave, Hong Kong 999077, Peoples R China; [Xie, Xulin; Zhai, Jiao; Zhou, Xiaoyu; Guo, Zhengjun; Lo, Pui-Chi; Yang, Mengsu] City Univ Hong Kong, Tung Biomed Sci Ctr, 83 Tat Chee Ave, Hong Kong 999077, Peoples R China; [Guo, Zhengjun] Chongqing Med Univ, Dept Oncol, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Zhu, Guangyu] City Univ Hong Kong, Dept Chem, Hong Kong 999077, Peoples R China; [Chan, Kannie W. Y.] City Univ Hong Kong, Dept Biomed Engn, Hong Kong 999077, Peoples R China"

通信作者："Yang, MS (通讯作者)，City Univ Hong Kong Shenzhen, Futian Res Inst, Dept Precis Diagnost & Therapeut Technol, Shenzhen 518057, Peoples R China.; Yang, MS (通讯作者)，City Univ Hong Kong, Dept Biomed Sci, 83 Tat Chee Ave, Hong Kong 999077, Peoples R China.; Yang, MS (通讯作者)，City Univ Hong Kong, Tung Biomed Sci Ctr, 83 Tat Chee Ave, Hong Kong 999077, Peoples R China."

来源：ADVANCED MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001115511900001

JCR分区：Q1

影响因子：27.4

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：magnetic particle imaging; medical diagnosis; image-guided therapy; magnetic nanoparticle tracers; vasculature abnormality

摘要："Magnetic particle imaging (MPI) is an emerging non-invasive tomographic technique based on the response of magnetic nanoparticles (MNPs) to oscillating drive fields at the center of a static magnetic gradient. In contrast to magnetic resonance imaging (MRI), which is driven by uniform magnetic fields and projects the anatomic information of the subjects, MPI directly tracks and quantifies MNPs in vivo without background signals. Moreover, it does not require radioactive tracers and has no limitations on imaging depth. This article first introduces the basic principles of MPI and important features of MNPs for imaging sensitivity, spatial resolution, and targeted biodistribution. The latest research aiming to optimize the performance of MPI tracers is reviewed based on their material composition, physical properties, and surface modifications. While the unique advantages of MPI have led to a series of promising biomedical applications, recent development of MPI in investigating vascular abnormalities in cardiovascular and cerebrovascular systems, and cancer are also discussed. Finally, recent progress and challenges in the clinical translation of MPI are discussed to provide possible directions for future research and development. Magnetic nanoparticle imaging is an emerging method based on tracking the distribution of magnetic nanoparticles (""tracers"") in vivo, where the imaging sensitivity, spatial resolution, and applications largely depend on the properties of the tracers. This article describes the imaging principles and features of MPI, the advancement in tracer structural design and synthesis, and the latest biomedical applications of MPI particularly in studying vasculature abnormality.image"

基金机构：Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone Shenzhen Park Project; Hong Kong Innovation and Technology Fund [MRP/045/21X]; City University of Hong Kong [9678223]; [HZQB-KCZYZ-2021017]

基金资助正文："This work was supported by grants from the Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone Shenzhen Park Project (HZQB-KCZYZ-2021017), Hong Kong Innovation and Technology Fund (MRP/045/21X), and City University of Hong Kong (Project #9678223)."