Intestinal Symptoms Among Children aged 2-7 Years with Autism Spectrum Disorder in 13 Cities of China

作者全名："Yang, Ting; Zhang, Qian; Chen, Li; Dai, Ying; Jia, Fei-Yong; Hao, Yan; Li, Ling; Zhang, Jie; Wu, Li-Jie; Ke, Xiao-Yan; Yi, Ming-Ji; Hong, Qi; Chen, Jin-Jin; Fang, Shuan-Feng; Wang, Yi-Chao; Wang, Qi; Jin, Chun-Hua; Chen, Jie; Li, Ting-Yu"

作者地址："[Yang, Ting; Zhang, Qian; Chen, Li; Dai, Ying; Chen, Jie; Li, Ting-Yu] Chongqing Med Univ, Childrens Hosp,Natl Clin Res Ctr Child Hlth & Diso, Chongqing Key Lab Childhood Nutr & Hlth, Minist Educ,Key Lab Child Dev & Disorders,Dept Chi, Chongqing, Peoples R China; [Jia, Fei-Yong] First Hosp Jilin Univ, Dept Dev & Behav Pediat, Changchun, Peoples R China; [Hao, Yan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan, Peoples R China; [Li, Ling] Hainan Women & Childrens Med Ctr, Dept Children Rehabil, Haikou, Peoples R China; [Zhang, Jie] Xian Childrens Hosp, Children Hlth Care Ctr, Xian, Peoples R China; [Wu, Li-Jie] Harbin Med Univ, Coll Publ Hlth, Dept Childrens & Adolescent Hlth, Harbin, Peoples R China; [Ke, Xiao-Yan] Nanjing Brain Hosp, Child mental Hlth Res Ctr, Nanjing, Peoples R China; [Yi, Ming-Ji] Qingdao Univ, Affiliated Hosp, Dept Child Hlth Care, Qingdao, Peoples R China; [Hong, Qi] Maternal & Child Hlth Hosp Baoan, Shenzhen, Peoples R China; [Chen, Jin-Jin] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Child Healthcare, Shanghai, Peoples R China; [Fang, Shuan-Feng] Zhengzhou Univ, Childrens Hosp, Zhengzhou, Peoples R China; [Wang, Yi-Chao] Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defect Res & Prevent, Changsha, Peoples R China; [Wang, Qi] Deyang Matern & Child Healthcare Hosp, Deyang, Sichuan, Peoples R China; [Jin, Chun-Hua] Capital Inst Pediat, Dept Children Hlth Care, Beijing, Peoples R China"

通信作者："Chen, J; Li, TY (通讯作者)，Chongqing Med Univ, Childrens Hosp,Natl Clin Res Ctr Child Hlth & Diso, Chongqing Key Lab Childhood Nutr & Hlth, Minist Educ,Key Lab Child Dev & Disorders,Dept Chi, Chongqing, Peoples R China."

来源：JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001116378600003

JCR分区：Q1

影响因子：3.2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Autism spectrum disorder; Intestinal symptoms; Symptom score

摘要："Background: Autism spectrum disorder (ASD) is a multifactorial, pervasive, neurodevelopmental disorder, of which intestinal symptoms collectively represent one of the most common comorbidities. Methods: In this study, 1,222 children with ASD and 1,206 typically developing (TD) children aged 2-7 years were enrolled from 13 cities in China. Physical measurement and basic information questionnaires were conducted in ASD and TD children. The Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and Autism Behavior Checklist (ABC) were used to evaluate the clinical symptoms of children with ASD. The six-item Gastrointestinal Severity Index (6-GSI) was used to evaluate the prevalence of intestinal symptoms in two groups. Results: The detection rates of constipation, stool odor, and total intestinal symptoms in ASD children were significantly higher than those in TD children (40.098% vs. 25.622%, 17.021% vs. 9.287%, and 53.601% vs. 41.294%, respectively). Autistic children presenting with intestinal comorbidity had significantly higher scores on the ABC, SRS, CARS, and multiple subscales than autistic children without intestinal symptoms, suggesting that intestinal comorbidity may exacerbates the core symptoms of ASD children. Conclusion: Intestinal dysfunction was significantly more common in autistic than in TD children. This dysfunction may aggravate the core symptoms of children with ASD."

基金机构：National Natural Science Foundation of China

基金资助正文："Thank you to all the children and parents who participated in this study. We thank members of the following participating units for their help in data collection and collation: Jun-yan Feng, Qiu Li, Jiang Zhu, Wei Wei, Lin Tian, Jin-zhu Zhao, Ming-yang Zou, Zhao-chuan Yang, Liang Xu, Bo Xiao, Yun Zhang, Tao-tao Jiang, Yan-jun Zhao, and Xi-yue Xiong."