"Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children"

作者全名："Zhang, Xian-Li; Zhang, Xi; Hua, Wang; Xie, Zheng-De; Liu, Han-Min; Zhang, Hai-Lin; Chen, Bi-Quan; Chen, Yuan; Sun, Xin; Xu, Yi; Shu, Sai-Nan; Zhao, Shun-Ying; Shang, Yun-Xiao; Cao, Ling; Jia, Yan-Hui; Lin, Luo-Na; Li, Jiong; Hao, Chuang-Li; Dong, Xiao-Yan; Lin, Dao-Jiong; Xu, Hong-Mei; Zhao, De-Yu; Zeng, Mei; Chen, Zhi-Min; Huang, Li-Su"

作者地址："[Zhang, Xian-Li; Hua, Wang; Jia, Yan-Hui; Lin, Luo-Na; Huang, Li-Su] Zhejiang Univ, Childrens Hosp, Dept Infect Dis, Sch Med, 3333 Bincheng Rd, Hangzhou 310052, Peoples R China; [Zhang, Xi] Shanghai Jiao Tong Univ, Clin Res Unit, Sch Med, Xin Hua Hosp, Shanghai, Peoples R China; [Xie, Zheng-De] Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing, Peoples R China; [Liu, Han-Min] Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Peoples R China; [Zhang, Hai-Lin] Wenzhou Med Univ, Affiliated Hosp 2, Dept Pediat Pulmonol, Wenzhou, Peoples R China; [Zhang, Hai-Lin] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China; [Chen, Bi-Quan] Anhui Prov Childrens Hosp, Dept Infect Dis, Hefei, Peoples R China; [Chen, Yuan] Hebei Med Univ, Hosp 2, Dept Pediat, Shijiazhuang, Peoples R China; [Sun, Xin] Fourth Mil Med Univ, Xijing Hosp, Dept Pediat, Xian, Peoples R China; [Xu, Yi] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Infect Dis, Guangzhou, Peoples R China; [Shu, Sai-Nan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan, Peoples R China; [Zhao, Shun-Ying] Capital Med Univ, Beijing Childrens Hosp, Dept Resp Dis, Beijing, Peoples R China; [Shang, Yun-Xiao] China Med Univ, Dept Resp, Shengjing Hosp, Shenyang 110004, Peoples R China; [Cao, Ling] Capital Inst Pediat, Childrens Hosp, Resp Dept, Beijing, Peoples R China; [Li, Jiong] Aarhus Univ, Dept Clin Epidemiol, Aarhus, Denmark; [Hao, Chuang-Li] Soochow Univ, Dept Respirol, Childrens Hosp, Suzhou, Peoples R China; [Dong, Xiao-Yan] Shanghai Jiao Tong Univ, Childrens Hosp Shanghai, Dept Resp, Childrens Hosp,Sch Med, Shanghai, Peoples R China; [Lin, Dao-Jiong] Hainan Women & Childrens Med Ctr, Dept Infect Dis, Haikou, Peoples R China; [Xu, Hong-Mei] Chongqing Med Univ, Dept Infect Dis, Childrens Hosp, Chongqing, Peoples R China; [Zhao, De-Yu] Nanjing Med Univ, Dept Resp Med, Childrens Hosp, Nanjing, Peoples R China; [Zeng, Mei] Fudan Univ, Childrens Hosp, Dept Infect Dis, 399 Wanyuan Rd, Shanghai 201102, Peoples R China; [Chen, Zhi-Min] Zhejiang Univ, Childrens Hosp, Dept Resp Dis, Sch Med, 3333 Binsheng Rd, Hangzhou 310052, Peoples R China"

通信作者："Huang, LS (通讯作者)，Zhejiang Univ, Childrens Hosp, Dept Infect Dis, Sch Med, 3333 Bincheng Rd, Hangzhou 310052, Peoples R China.; Zeng, M (通讯作者)，Fudan Univ, Childrens Hosp, Dept Infect Dis, 399 Wanyuan Rd, Shanghai 201102, Peoples R China.; Chen, ZM (通讯作者)，Zhejiang Univ, Childrens Hosp, Dept Resp Dis, Sch Med, 3333 Binsheng Rd, Hangzhou 310052, Peoples R China."

来源：WORLD JOURNAL OF PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001116542400001

JCR分区：Q1

影响因子：6.1

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Consensus prevention; Respiratory syncytial virus; Treatment

摘要："BackgroundRespiratory syncytial virus (RSV) is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years, representing a major global healthcare burden. There is a great unmet need for new agents and universal strategies to prevent RSV infections in early life. A multidisciplinary consensus development group comprising experts in epidemiology, infectious diseases, respiratory medicine, and methodology aims to develop the current consensus to address clinical issues of RSV infections in children.Data sourcesThe evidence searches and reviews were conducted using electronic databases, including PubMed, Embase, Web of Science, and the Cochrane Library, using variations in terms for ""respiratory syncytial virus"", ""RSV"", ""lower respiratory tract infection"", ""bronchiolitis"", ""acute"", ""viral pneumonia"", ""neonatal"", ""infant"" ""children"", and ""pediatric"".ResultsEvidence-based recommendations regarding diagnosis, treatment, and prevention were proposed with a high degree of consensus. Although supportive care remains the cornerstone for the management of RSV infections, new monoclonal antibodies, vaccines, drug therapies, and viral surveillance techniques are being rolled out.ConclusionsThis consensus, based on international and national scientific evidence, reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV infections. Further improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.3Zrgg9eFrSMG87iwcWiBtJVideo Abstract (MP4 142103 KB)ConclusionsThis consensus, based on international and national scientific evidence, reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV infections. Further improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.3Zrgg9eFrSMG87iwcWiBtJVideo Abstract (MP4 142103 KB)"

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