"Single-cell aggrephagy-related patterns facilitate tumor microenvironment intercellular communication, influencing osteosarcoma progression and prognosis"

作者全名："Jiang, Yunsheng; Ning, Yun; Cheng, Shidi; Huang, Yinde; Deng, Muhai; Chen, Cheng"

作者地址："[Jiang, Yunsheng; Deng, Muhai; Chen, Cheng] Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China; [Ning, Yun] Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China; [Ning, Yun] Southwest Hosp, Southwest Canc Ctr, Chongqing 400038, Peoples R China; [Cheng, Shidi] Army Med Ctr PLA, Dept Hematol, Chongqing 400012, Peoples R China; [Huang, Yinde] Chongqing Gen Hosp, Dept Breast & Thyroid Surg, Chongqing 401147, Peoples R China"

通信作者："Chen, C (通讯作者)，Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China."

来源：APOPTOSIS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001116625800002

JCR分区：Q1

影响因子：6.1

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Osteosarcoma; Aggrephagy; Bioinformatics; Prognosis

摘要："Osteosarcoma, a common malignant tumor in children, has emerged as a major threat to the life and health of pediatric patients. Presently, there are certain limitations in the diagnosis and treatment methods for this disease, resulting in inferior therapeutic outcomes. Therefore, it is of great importance to study its pathogenesis and explore innovative approaches to diagnosis and treatment. In this study, a non-negative matrix decomposition method was employed to conduct a comprehensive investigation and analysis of aggregated autophagy-related genes within 331,394 single-cell samples of osteosarcoma. Through this study, we have elucidated the intricate communication patterns among various cells within the tumor microenvironment. Based on the classification of aggregated autophagy-related genes, we are not only able to more accurately predict patients' prognosis but also offer robust guidance for treatment strategies. The findings of this study hold promise for breakthroughs in the diagnosis and treatment of osteosarcoma, intervention of aggrephagy is expected to improve the survival rate and quality of life of osteosarcoma patients."

基金机构：Science and Technology Projects of Chongqing Education Commission

基金资助正文：No Statement Available