Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms

作者全名："Wei, Guizheng; Lu, Ke; Umar, Muhammad; Zhu, Zhenglin; Lu, William W.; Speakman, John R.; Chen, Yan; Tong, Liping; Chen, Di"

作者地址："[Wei, Guizheng; Chen, Yan] Guangxi Med Univ, Affiliated Hosp 1, Dept Bone & Joint Surg, Nanning 530021, Peoples R China; [Wei, Guizheng; Lu, Ke; Umar, Muhammad; Tong, Liping; Chen, Di] Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Comp Aided Drug Discovery, Shenzhen 518055, Peoples R China; [Wei, Guizheng; Lu, Ke; Umar, Muhammad; Lu, William W.; Chen, Di] Chinese Acad Sci, Fac Pharmaceut Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China; [Zhu, Zhenglin] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped Surg, Chongqing 400016, Peoples R China; [Speakman, John R.] Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Energy Metab & Reprod, Shenzhen 518055, Peoples R China"

通信作者："Chen, Y (通讯作者)，Guangxi Med Univ, Affiliated Hosp 1, Dept Bone & Joint Surg, Nanning 530021, Peoples R China.; Tong, LP (通讯作者)，Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Comp Aided Drug Discovery, Shenzhen 518055, Peoples R China."

来源：BONE RESEARCH

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001117821300001

JCR分区：Q1

影响因子：14.3

年份：2023

卷号：11

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：　

摘要："Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the association between metabolic abnormalities and OA, particularly in younger individuals. Metabolic abnormalities, such as obesity and type II diabetes, are strongly linked to OA, and they affect both weight-bearing and non-weight-bearing joints, thus suggesting that the pathogenesis of OA is more complicated than the mechanical stress induced by overweight. This review aims to explore the recent advances in research on the relationship between metabolic abnormalities and OA risk, including the impact of abnormal glucose and lipid metabolism, the potential pathogenesis and targeted therapeutic strategies."

基金机构："National Natural Science Foundation of China (National Science Foundation of China) [2021YFB3800800]; National Key Research and Development Program of China [82030067, 82161160342, 82250710174, 82360429, 82172397]; National Natural Science Foundation of China (NSFC) [2022JJA141126]; National Science Foundation of Guangxi [2019M650235]; Advanced Innovation Teams and Xinghu Scholars Program of Guangxi Medical University, China Postdoctoral Science Foundation [2021003]; Key R&D Project of Qingxiu District, Nanning, Guangxi [HKU-17101821]; Hong Kong RGC; SIAT Innovation Program for Excellent Young Researchers"

基金资助正文："This work was supported by the National Key Research and Development Program of China (2021YFB3800800) to L.T. and D.C. This project was also supported by the National Natural Science Foundation of China (NSFC) grants (82030067, 82161160342 and 82250710174) to D.C., grant 82360429 to Y.C and grant 82172397 to L.T. This project was also supported by National Science Foundation of Guangxi (2022JJA141126), Advanced Innovation Teams and Xinghu Scholars Program of Guangxi Medical University, China Postdoctoral Science Foundation (2019M650235), Key R&D Project of Qingxiu District, Nanning, Guangxi (2021003) to Y.C., and the Hong Kong RGC grant HKU-17101821 to W.W.L. and D.C., and SIAT Innovation Program for Excellent Young Researchers to K.L."