Comprehensive analysis of the association between inflammation indexes and complications in patients undergoing pancreaticoduodenectomy

作者全名："Ma, Minghua; Li, Guo; Zhou, Baoyong; Li, Kaili; Wu, Zhongjun; Kong, Lingwang; Liu, Maoyun; Liu, Miao; Zhang, Cheng; Yu, Huarong; Wang, Shuaiqi; Huang, Zuotian; Zong, Kezhen"

作者地址："[Ma, Minghua; Li, Guo; Zhou, Baoyong; Li, Kaili; Wu, Zhongjun; Huang, Zuotian; Zong, Kezhen] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Chongqing, Peoples R China; [Ma, Minghua; Li, Kaili; Yu, Huarong; Wang, Shuaiqi; Huang, Zuotian] Chongqing Med Univ, Chongqing, Peoples R China; [Kong, Lingwang; Liu, Maoyun; Liu, Miao; Zhang, Cheng; Wang, Shuaiqi; Huang, Zuotian] Chongqing Univ, Canc Hosp, Chongqing, Peoples R China"

通信作者："Huang, ZT; Zong, KZ (通讯作者)，Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Chongqing, Peoples R China.; Wang, SQ; Huang, ZT (通讯作者)，Chongqing Med Univ, Chongqing, Peoples R China.; Wang, SQ; Huang, ZT (通讯作者)，Chongqing Univ, Canc Hosp, Chongqing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001117840700001

JCR分区：Q1

影响因子：5.7

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：pancreaticoduodenectomy; blood routine examination; inflammatory indexes; restricted cubic splines (RCS); complication

摘要："BackgroundDuring clinical practice, routine blood tests are commonly performed following pancreaticoduodenectomy (PD). However, the relationship between blood cell counts, inflammation-related indices, and postoperative complications remains unclear.MethodWe conducted a retrospective study, including patients who underwent PD from October 2018 to July 2023 at the First Hospital of Chongqing Medical University, and compared baseline characteristics and clinical outcomes among different groups. Neutrophil count (NC), platelet count (PLT), lymphocyte count (LC), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and the product of platelet count and neutrophil count (PPN) were derived from postoperative blood test results. We investigated the association between these indicators and outcomes using multivariable logistic regression and restricted cubic spline analysis. The predictive performance of these indicators was assessed by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve and decision curve analysis (DCA).ResultA total of 232 patients were included in this study. Multivariate logistic regression and restricted cubic spline analysis showed that all indicators, except for PLT, were associated with clinical postoperative pancreatic fistula (POPF). SII, NLR, and NC were linked to surgical site infection (SSI), while SII, NLR, and PLR were correlated with CD3 complication. PLT levels were related to postoperative hemorrhage. SII (AUC: 0.729), NLR (AUC: 0.713), and NC (AUC: 0.706) effectively predicted clinical POPF.ConclusionIn patients undergoing PD, postoperative inflammation-related indices and blood cell counts are associated with various complications. NLR and PLT can serve as primary indicators post-surgery for monitoring complications."

基金机构：Chongqing Research Performance Incentive and Guidance Project [cstc2022jxjl120032]; Chongqing technology innovation and application development key project [cstc2021jscx-gksbX0060]; Natural Science Foundation of Chongqing [CSTB2023NSCQ- BHX0131]

基金资助正文："The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research is supported by Chongqing Research Performance Incentive and Guidance Project (cstc2022jxjl120032), Chongqing technology innovation and application development key project (cstc2021jscx-gksbX0060) and the Natural Science Foundation of Chongqing (CSTB2023NSCQ- BHX0131)."