Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer's Disease

作者全名："Wang, Qunxian; Guo, Shipeng; Hu, Dongjie; Dong, Xiangjun; Meng, Zijun; Jiang, Yanshuang; Feng, Zijuan; Zhou, Weihui; Song, Weihong"

作者地址："[Wang, Qunxian; Guo, Shipeng; Hu, Dongjie; Dong, Xiangjun; Meng, Zijun; Jiang, Yanshuang; Feng, Zijuan; Zhou, Weihui; Song, Weihong] Chongqing Med Univ, China Int Sci & Technol Cooperat Base Dev & Crit D, Natl Clin Res Ctr Child Hlth & Disorders,Chongqing, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China; [Song, Weihong] Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Sch Mental Hlth, Inst Aging Key Lab Alzheimers Dis Zhejiang Prov, Wenzhou 325035, Peoples R China; [Song, Weihong] Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325001, Zhejiang, Peoples R China"

通信作者："Zhou, WH; Song, WH (通讯作者)，Chongqing Med Univ, China Int Sci & Technol Cooperat Base Dev & Crit D, Natl Clin Res Ctr Child Hlth & Disorders,Chongqing, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China."

来源：NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001119407200001

JCR分区：Q3

影响因子：3.3

年份：2024

卷号：536

期号：　

开始页：1

结束页：11

文献类型：Article

关键词：Key words: Alzheimer's disease (AD); Ap; pyroptosis; GSDME; cognitive impairments.

摘要："p protein (Ap) is a critical factor in the pathogenesis of Alzheimer's disease (AD). Ap induces apoptosis, and gasdermin-E (GSDME) expression can switch apoptosis to pyroptosis. In this study, we demonstrated that GSDME was highly expressed in the hippocampus of APP23/PS45 mouse models compared to that in age-matched wild-type mice. Ap treatment induced pyroptosis by active caspase-3/GSDME in SH-SY5Y cells. Furthermore, the knockdown of GSDME improved the cognitive impairments of APP23/PS45 mice by alleviating inflammatory response. Our findings reveal that GSDME, as a modulator of Ap and pyroptosis, plays a potential role in Alzheimer's disease pathogenesis and shows that GSDME is a therapeutic target for AD.(c) 2023 IBRO. Published by Elsevier Ltd. All rights reserved."

基金机构：Key Laboratory of Alzheimer's Disease of Zhejiang Province; Zhejiang Provincial Clinical Research Center for Mental Disorders

基金资助正文：The study was partially supported by funding to Key Laboratory of Alzheimer's Disease of Zhejiang Province and Zhejiang Provincial Clinical Research Center for Mental Disorders (WS) .