Thrombopoietin levels in sepsis and septic shock - a systematic review and meta-analysis

作者全名："Liu, Chang; Goerlich, Dennis; Lowell, Clifford A.; Italiano, Joseph E.; Rossaint, Jan; Bender, Markus; Zarbock, Alexander; Margraf, Andreas"

作者地址："[Liu, Chang; Rossaint, Jan; Zarbock, Alexander; Margraf, Andreas] Univ Hosp Munster, Dept Anesthesiol Intens Care & Pain Med, Albert Schweitzer Campus 1,Bldg A1, Munster, Germany; [Margraf, Andreas] Queen Mary Univ London, William Harvey Res Inst, Fac Med & Dent, Ctr Biochem Pharmacol, London EC1M 6BQ, England; [Liu, Chang] Chongqing Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Chongqing, Peoples R China; [Goerlich, Dennis] Univ Munster, Inst Biostat & Clin Res, Munster, Germany; [Lowell, Clifford A.] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA USA; [Italiano, Joseph E.] Harvard Med Sch, Dept Surg, Boston, MA USA; [Italiano, Joseph E.] Boston Childrens Hosp, Vasc Biol Program, Boston, MA USA; [Bender, Markus] Univ Hosp Wurzburg, Inst Expt Biomed, Chair 1, Wurzburg, Germany"

通信作者："Margraf, A (通讯作者)，Univ Hosp Munster, Dept Anesthesiol Intens Care & Pain Med, Albert Schweitzer Campus 1,Bldg A1, Munster, Germany.; Margraf, A (通讯作者)，Queen Mary Univ London, William Harvey Res Inst, Fac Med & Dent, Ctr Biochem Pharmacol, London EC1M 6BQ, England."

来源：CLINICAL CHEMISTRY AND LABORATORY MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001120235400001

JCR分区：Q1

影响因子：3.8

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：sepsis; thrombopoietin; inflammation

摘要："Objectives Sepsis is a life-threatening condition implicating an inadequate activation of the immune system. Platelets act as modulators and contributors to immune processes. Indeed, altered platelet turnover, thrombotic events, and changes in thrombopoietin levels in systemic inflammation have been reported, but thrombopoietin-levels in sepsis and septic-shock have not yet been systematically evaluated. We therefore performed a meta-analysis of thrombopoietin (TPO)-levels in patients with sepsis.Methods Two independent reviewers screened records and full-text articles for inclusion. Scientific databases were searched for studies examining thrombopoietin levels in adult sepsis and septic-shock patients until August 1st 2022.Results Of 95 items screened, six studies met the inclusion criteria, including 598 subjects. Both sepsis and severe sepsis were associated with increased levels of thrombopoietin (sepsis vs. control: standardized mean difference 3.06, 95 % CI 1.35-4.77; Z=3.50, p=0.0005) (sepsis vs. severe sepsis: standardized mean difference -1.67, 95 % CI -2.46 to -0.88; Z=4.14, p<0.0001). TPO-levels did not show significant differences between severe sepsis and septic shock patients but differed between sepsis and inflammation-associated non-septic controls. Overall, high heterogeneity and low sample size could be noted.Conclusions Concluding, increased levels of thrombopoietin appear to be present both in sepsis and severe sepsis with high heterogeneity but thrombopoietin does not allow to differentiate between severe sepsis and septic-shock. TPO may potentially serve to differentiate sepsis from non-septic trauma and/or tissue damage related (systemic) inflammation. Usage of different assays and high heterogeneity demand standardization of methods and further large multicenter trials."

基金机构：Deutsche Forschungsgemeinschaft

基金资助正文：No Statement Available