Enterogenic metabolomics signatures of depression: what are the possibilities for the future

作者全名："Zhang, Yangdong; Chen, Xueyi; Mo, Xiaolong; Xiao, Rui; Cheng, Qisheng; Wang, Haiyang; Liu, Lanxiang; Xie, Peng"

作者地址："[Zhang, Yangdong; Mo, Xiaolong; Cheng, Qisheng; Wang, Haiyang; Liu, Lanxiang; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Zhang, Yangdong; Chen, Xueyi; Mo, Xiaolong; Xiao, Rui; Cheng, Qisheng; Wang, Haiyang; Liu, Lanxiang; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, NHC Key Lab Diag & Treatment Brain Funct Dis, Chongqing, Peoples R China; [Chen, Xueyi; Xiao, Rui] Chongqing Med Univ, Fac Basic Med, Dept Pathol, Chongqing, Peoples R China; [Liu, Lanxiang; Xie, Peng] Chongqing Med Univ, Yongchuan Hosp, Dept Neurol, Chongqing, Peoples R China"

通信作者："Xie, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, NHC Key Lab Diag & Treatment Brain Funct Dis, Chongqing, Peoples R China."

来源：EXPERT REVIEW OF PROTEOMICS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001120770900001

JCR分区：Q1

影响因子：3.8

年份：2023

卷号：　

期号：　

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结束页：　

文献类型：Review; Early Access

关键词：Microbiome; metabolite; depression; gut; metabolomics; microbiome-gut-brain axis

摘要："IntroductionAn increasing number of studies indicate that the microbiota-gut-brain axis is an important pathway involved in the onset and progression of depression. The responses of the organism (or its microorganisms) to external cues cannot be separated from a key intermediate element: their metabolites.Areas CoveredIn recent years, with the rapid development of metabolomics, an increasing amount of metabolites has been detected and studied, especially the gut metabolites. Nevertheless, the increasing amount of metabolites described has not been reflected in a better understanding of their functions and metabolic pathways. Moreover, our knowledge of the biological interactions among metabolites is also incomplete, which limits further studies on the connections between the microbial-entero-brain axis and depression.Expert OpinionThis paper summarizes the current knowledge on depression-related metabolites and their involvement in the onset and progression of this disease. More importantly, this paper summarized metabolites from the intestine, and defined them as enterogenic metabolites, to further clarify the function of intestinal metabolites and their biochemical cross-talk, providing theoretical support and new research directions for the prevention and treatment of depression."

基金机构："Natural Science Foundation Project of China [81820108015, 82201683]; China Postdoctoral Science Foundation [2021M693926, 2020TQ0393, 2020M683634XB]; Special Funding for Chongqing Postdoctoral Research Projects [2021XMT001]"

基金资助正文："This work was supported by the Natural Science Foundation Project of China [No. 81820108015, No. 82201683], the China Postdoctoral Science Foundation [No. 2021M693926, No. 2020TQ0393, and No. 2020M683634XB], Special Funding for Chongqing Postdoctoral Research Projects [2021XMT001]"