Comment on "An Injectable Hydrogel to Modulate <i>T</i> Cells for Cancer Immunotherapy"

作者全名："Lin, Liangbin; Zhang, Sunfu; Yang, Wenyong"

作者地址："[Lin, Liangbin; Zhang, Sunfu; Yang, Wenyong] Chongqing Med Univ, Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Med Res Ctr,Affiliated Hosp,Chengdu Hosp 2, Chengdu 610014, Peoples R China"

通信作者："Zhang, SF; Yang, WY (通讯作者)，Chongqing Med Univ, Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Med Res Ctr,Affiliated Hosp,Chengdu Hosp 2, Chengdu 610014, Peoples R China."

来源：SMALL

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001120828000001

JCR分区：Q1

影响因子：13

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Editorial Material; Early Access

关键词：T cell exhuastion; Tumor Infiltrating Lymphocytes; tumor immunology; CD8(+) T cells

摘要："Recent clinical successes of immune checkpoint blockade (ICB) therapies represents a milestone as a novel anti-tumor strategy beyond surgery, radiotherapy, chemotherapy, and targeted therapy in cancer therapy. T cells, especially CD8(+) T cells, play crucial roles in anti-tumor immune responses. However, most T cells in the tumor microenvironment express high inhibitory receptors, such as PD-1, TIM-3, and LAG-3, and decreased T cell response in response to stimuli. Applying ICB therapies, such as anti-PD-1, promotes T cell activation and increases cytotoxic T lymphocyte (CTL) response, leading to the enhanced anti-tumor immune response in patients with malignancy. Therefore, studies aimed to define novel targets that can restrain T cell terminal exhaustion are urgently required to provide new strategies for patients resistant to immunotherapy. The previously published study by Zhang et al. (An Injectable Hydrogel to Modulate T Cells for Cancer Immunotherapy, ) introduces a new type of injectable hydrogel that can regulate the function of T cells, thereby improving their effectiveness in cancer immunotherapy. However, it remains to be discussed for its conclusion, as the flow cell assay of this article may not be proper."

基金机构："Chengdu Science and Technology Bureau; Sichuan Science and Technology Department [23NSFSC0677, 2021YFS0082]; [ZX20210805420]; [2021084]"

基金资助正文："This work was supported by the Sichuan Science and Technology Department (23NSFSC0677, 2021YFS0082) and Chengdu Science and Technology Bureau (ZX20210805420, 2021084)."