Age-related differences in IgE between childhood and adulthood allergic asthma: Analysis of NHANES 2005-2006

作者全名："Fang, Heping; Li, Juan; Ren, Luo; Liu, Enmei"

作者地址："[Ren, Luo; Liu, Enmei] Chongqing Med Univ, Dept Resp Med, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp,Minist Educ,Key Lab Child Dev & Dis, Chongqing, Peoples R China; [Ren, Luo; Liu, Enmei] Chongqing Med Univ, Childrens Hosp, Dept Resp Med, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China"

通信作者："Ren, L; Liu, EM (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Resp Med, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：WORLD ALLERGY ORGANIZATION JOURNAL

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001121359700001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：16

期号：12

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Background: Asthma exhibits varying clinical features in children and adults. However, previous studies have mainly focused on the clinical significance of immunoglobulin E (IgE) in the diagnosis and treatment of asthma, disregarding the characteristics of IgE and its relevant factors.Objective: This study aimed to gain a better understanding of the differences in the character-istics of IgE between childhood and adulthood allergic asthma (AA). Methods: Patients with AA from the 2005 to 2006 National Health and Nutrition Examination Survey (NHANES) were divided into 3 groups based on their current age and onset age of AA: childhood AA (Group 1), childhood-onset adult AA (Group 2), and adulthood-onset AA (Group 3). Intragroup analysis and intergroup comparison were carried out, focusing on the characteristics and relevant factors of IgE, as well as the clinical relevance of total IgE (total IgE, tIgE) and allergen-specific IgE (allergen-specific IgE, sIgE).Results: A total of 424 patients were analyzed, including 187 with childhood AA, 132 with childhood-onset adult AA, and 105 with adulthood-onset AA. The concentration of tIgE was found to be higher in Group 1 (268.0, 118.0-686.0 kU/L) than in Group 2 (224.0, 78.0-494.0 kU/L) and Group 3 (165.0, 74.4-350.5 kU/L). The sensitization rates did not differ between Group 1 and Group 2 but were higher compared with Group 3, particularly for Alternaria-sIgE (50.3% and 46.2% vs 15.2%) and Aspergillus-sIgE (43.9% and 37.1% vs 16.2%). In Group 1, there was a negative correlation between pollen-sIgEs and indoor allergens, but this correlation was not commonly observed in Group 2 and Group 3. On the other hand, in Group 1, environmental chemicals such as phthalates, polyaromatic hydrocarbons, trihalomethanes, and phenols showed a positive correlation with IgE. However, a greater number of chemicals was observed in Group 2 and Group 3, including cotinine, metals, trihalomethanes, phthalates, phenols, and other volatile organic compounds (VOCs). Furthermore, in Group 1, IgE was positively correlated with asthma-related issues such as emergency visits, absenteeism, limited activities, and medication needs. These correlations were less common in Group 2 and Group 3, particularly in Group 3."

基金机构：Science and Technology Research Program of Chongqing Municipal Education Commission [KJZD-M202200404]

基金资助正文：This study was supported by the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJZD-M202200404) .