Intravoxel incoherent motion diffusion-weighted imaging for evaluating the pancreatic perfusion in cirrhotic patients

作者全名："Hu, Ran; Zeng, Guo-Fei; Fang, Yu; Nie, Lisha; Liang, Hui-Lou; Wang, Zhi-Gang; Yang, Hua"

作者地址："[Hu, Ran; Zeng, Guo-Fei; Fang, Yu; Yang, Hua] Chongqing Hosp Tradit Chinese Med, Dept Radiol, 6 Panxi 7th Rd, Chongqing 400021, Peoples R China; [Wang, Zhi-Gang] Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, 76 Linjiang Rd, Chongqing 400010, Peoples R China; [Nie, Lisha; Liang, Hui-Lou] GE Healthcare, MR Res China, Beijing, Peoples R China"

通信作者："Yang, H (通讯作者)，Chongqing Hosp Tradit Chinese Med, Dept Radiol, 6 Panxi 7th Rd, Chongqing 400021, Peoples R China.; Wang, ZG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Ultrasound, 76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：ABDOMINAL RADIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001121649700002

JCR分区：Q2

影响因子：2.3

年份：2024

卷号：49

期号：2

开始页：492

结束页：500

文献类型：Article; Early Access

关键词：Pancreas; Liver cirrhosis; Perfusion; IVIM; MRI

摘要："PurposeTo assess the characteristics of pancreatic perfusion in normal pancreas versus cirrhotic patients using intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI).MethodsA total of 67 cirrhotic patients and 33 healthy subjects underwent IVIM on a 3.0 T MRI scanner. Diffusion coefficient (ADCslow), pseudo-diffusion coefficient (ADCfast), and perfusion fraction (f) were calculated based on the bi-exponential model. The pancreatic IVIM-derived parameters were then compared. In the cirrhotic group, the relationship was analyzed between IVIM-derived pancreatic parameters and different classes of hepatic function as determined by the Child-Pugh classification. Also, the pancreatic IVIM-derived parameters were compared among different classes of cirrhosis as determined by the Child-Pugh classification.ResultsThe f value of the pancreas in cirrhotic patients was significantly lower than that in normal subjects (p = 0.01). In the cirrhotic group, the f value of the pancreas decreased with the increase of the Child-Pugh classification (R = - 0.49, p = 0.00). The f value of the pancreas was significantly higher in Child-Pugh class A patients than in class B and C patients (p = 0.02, 0.00, respectively), whereas there was no significant difference between class B and C patients (p = 0.16).ConclusionThe IVIM-derived perfusion-related parameter (f value) could be helpful for the evaluation of pancreatic perfusion in liver cirrhosis. Our data also suggest that the blood perfusion decrease in the pancreas is present in liver cirrhosis, and the pancreatic perfusion tends to decrease with the increasing severity of hepatic function.Trial registrationTrial registration number is 2021-ky-68 and date of registration for prospectively registered trials is February 23, 2022."

基金机构："the National Natural Science Foundation of China; Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China"

基金资助正文："The authors would like to express their deepest gratitude to the technicians who performed IVIM-MRI scans on all subjects in the department of radiology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China."