Competing risk analysis of cardiovascular death in breast cancer: evidence from the SEER database

作者全名："He, Jiahui; Wang, Shunde; Liu, Hui; Duan, Cheng; Zhang, Hao; Wen, Fei; Zhang, Chengsheng"

作者地址："[He, Jiahui; Duan, Cheng; Zhang, Hao; Wen, Fei; Zhang, Chengsheng] Chongqing Med Univ, Dept Thyroid & Breast & Vasc Surg, Banan Hosp, 659 Yunan Ave, Chongqing 401320, Peoples R China; [Wang, Shunde] ChenJiaqiao Hosp ShaPingba Dist Chongqing City, Dept Urol, Chongqing, Peoples R China; [Liu, Hui] Chongqing Tradit Chinese Med Hosp, Supervis & Audit Div, Chongqing, Peoples R China"

通信作者："Wen, F; Zhang, CS (通讯作者)，Chongqing Med Univ, Dept Thyroid & Breast & Vasc Surg, Banan Hosp, 659 Yunan Ave, Chongqing 401320, Peoples R China."

来源：TRANSLATIONAL CANCER RESEARCH

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001122479700001

JCR分区：Q4

影响因子：1.5

年份：2023

卷号：12

期号：12

开始页：3591

结束页：3603

文献类型：Article; Early Access

关键词：Breast cancer (BC); cardiovascular disease (CVD); cardiovascular mortality (CVM); Surveillance; Epidemiology and End Results (SEER); competing risk regression

摘要："Background: Cardiovascular disease (CVD) is the leading cause of death for all non-cancer deaths among breast cancer (BC) patients. The aim of this study was to investigate the risk of cardiovascular mortality (CVM) in patients with BC. Methods: Patients diagnosed with primary BC between 2010 and 2018 were identified through the Surveillance, Epidemiology and End Results (SEER) database. The standardized mortality ratio (SMR) for CVD was calculated to compare the CVM of BC patients with that of the general population. Multivariate competing risk models were performed to identify predictors of CVM in BC patients. Results: Overall, 399,014 BC patients were included from the SEER database, of whom 7,023 (1.8%) suffered death from CVD. The significantly higher overall SMR of CVM was observed in BC patients [SMR =4.84, 95% confidence interval (CI): 4.72-4.95]. Multivariate competing risk regression analysis revealed that age, race, American Joint Committee on Cancer (AJCC) stage, year of diagnosis, estrogen receptor (ER) status, progesterone receptor (PR) status, human epidermal growth factor receptor 2 (HER2) status, BC subtype, surgery, chemotherapy, radiation therapy, and median household income as independent predictors of CVM in BC patients. Conclusions: Compared to the general population, BC patients have a higher risk of experiencing CVM during the follow-up period after diagnosis. Early detection and intervention of cardiovascular risk factors would improve overall survival (OS) of BC patients."

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